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P2026
Utilizing Techniques in Developing & Optimizing Assay Paradigms to Increase Throughput in Screening Small Libraries & Special Compound Collections
Presenter Amanda Kemmerer, Merck, USA
Additional Authors: Scott D. Mosser, Rodney A. Bednar, James Barrow, George Hartman, Steven Young
Many pharmaceutical companies have small sample collections that can range in size from approximately 1,000 to 100,000 compounds.  Oftentimes, the projects for which they are screened do not meet criteria required for a high-throughput scerening initiative. As a result, the scientist performing routine screening is often responsible for testing these collections on their own time. The screening of such collections can be overwhelming to the scientist, and can require a substantial amount of time to accomplish. Ultimately, this can lead to delays in the generation of new lead compounds, as well as potentially inconsistent data from variations in assay conditions over time. This poster will demonstrate how our particular group, FAST, works in one way to facilitate optimizing assays geared toward increasing the throughput of screening small compound collections.