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P2049
A New Aquesous Solubility Screen High-Throughput Sonication
Presenter Kevin Oldenburg, MatriCal, USA
Additional Authors: Harri Härmä, Anita Rozwandowicz, Eija Martikkala, Mirva Koskelin, Pekka Hänninen, Heini Frang
Poor compound solubility and inefficient methods to drive compounds to their thermodynamic solubility can decrease productivity in drug discovery and development. Although the concept of high-throughput screening has been integrated into the pharmaceutical drug discovery process it is not as of yet useful in compound solubility as the dissolution of drug compounds to saturation is still reliant on the inherently low-throughput and time consuming shake-flask method. The SonicMan (MatriCal, Inc., Spokane, WA) introduces a high-throughput method for compound dissolution with a microplate format sonicator. In this study the SonicMan is comparatively evaluated against the conventional shake-flask method for their respective compound dissolution properties. Results indicate that the SonicMan is a viable option for determining aqueous drug solubility in this high-throughput era of drug research