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Advancing The Science of Drug Discovery
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Scientific Posters Archive Site |  |
SBS 14th Annual Conference & Exhibition
April 6 - 10, 2008 . America's Center . St. Louis, MO
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| Agrawal, Sony | ||
| Multiplexing HCV Replicon Luciferase Assay With Cell-Titer Blue Toxicity Assay In HTS Format View Abstract | ||
| Ahmadyar, Shekeba | ||
| Evaluation of Nanoliter Transfer using Acoustic Droplet Ejection View Abstract | ||
| Albert, Keith | ||
| Liquid Delivery Errors – The Impact of Laboratory Conditions on Pipetting Performance View Abstract | ||
| Alderton, Alexandra | ||
| The Impact of Automated Clone Selection on the Cell Line Generation Process View Abstract | ||
| Alworth, Samuel | ||
| Automatic Transfluor Assay Analysis using Machine Learning View Abstract | ||
| Amsden, Bruce | ||
| New SA-PE Conjugates Reduce Capture-Antibody-Specific Background in Sandwich Immunoassays Performed Using Luminex® xMAP® Technology View Abstract View Poster | ||
| Anhalt, Michael | ||
| Cell Cycle Drug Profiling by BrdU Incorporation, Histone H3 Phosphorylation, Cytoskeletal Rearrangement, & Cell Morphology Changes by Multiplexed High-Content Screening Assays View Abstract View Poster | ||
| Ann McKenna, Beth | ||
| Validation of a Functional Screening Assay for Glycine Transporter 1 Inhibitors Using Cryopreserved Cells View Abstract | ||
| Armstrong, Lucas | ||
| Adrenergic Receptor Family Membrane Preparation Array With Millipore's MultiScreenHTS Glass Fiber Filter Plates View Abstract | ||
| Arnold, Don | ||
| Real-time Reaction Monitoring & Enzyme Kinetics Measurements on the ExpressLC platform View Abstract | ||
| Asai, Yasuyuki | ||
| QT Prolongation Assay Using Beating Cardiomyocyte Derived From Monkey ES Cell View Abstract | ||
| Ball, Andrew | ||
| Multiplexed High-content Screening Assays for Cell Cycle Analysis & Cytotoxicity Profiling View Abstract | ||
| Baranowski, Timothy | ||
| Overt Toxicity Screening Assay Using Live Z-TagSM Zebrafish View Abstract View Poster | ||
| Beacham, Daniel | ||
| Primary Human Cells & BacMam Target Delivery in a Novel, High-Throughput Assay of hERG Function View Abstract View Poster | ||
| Becker, Bruno | ||
| Validation of Low Volume 1536 “Assay Ready” Compound Plates for a Nuclear Hormone Receptor Screen. View Abstract View Poster | ||
| Bermingham, Alun | ||
| Mechanistic evaluation of natural product inhibitors of HIV-1 RNase View Abstract | ||
| Beyermann-Lopata, Birgit | ||
| HitHunter™ cAMP Assays Versatile Assays Validated for Multiple Applications View Abstract | ||
| Bielefeld, Martina | ||
| Serine/Threonine Kinase Profiling using the LANCE® Ultra KinaSelect™ Ser/Thr Kit View Abstract View Poster | ||
| Birnbaum, Eva | ||
| Label-Free Characterization of Proteins Using Acoustic Droplet Ejection Deposition & Advanced X-Ray Technology Measurement View Abstract View Poster | ||
| Biros, Michael | ||
| Toward Routine Assays in 200 nL Volumes View Abstract | ||
| Boll, Andreas | ||
| Rapid Generation of Epitope-Specific Recombinant Antibodies Using in vitro Selection Technology View Abstract View Poster | ||
| Bounds, Sidney | ||
| Endogenous Receptor Characterization in Normal Lung Cells by Cellular Dielectric Spectroscopy & RNA Interference View Abstract | ||
| Bourdon, David | ||
| Complete Automated Solution for HLA Antibody Detection Using Multiplex xMAP Technology View Abstract | ||
| Bowen, Wayne | ||
| Label-free Analysis of Tissue Sections & Cells Using Laser Scanning Reflectance Imaging View Abstract | ||
| Bradshaw, John | ||
| The Effects of Pipette Tip Material & Sterilization on the Retention of Aqueous Liquids View Abstract | ||
| Brady, Lee | ||
| Advances in High-Throughput Screening with the New LumiLux® CS Cellular luminescence Platform. View Abstract View Poster | ||
| Brazzill, Dianne | ||
| Automation of AlphaLISA Insulin & VEGF Immunoassays on JANUS Liquid Handling Workstation View Abstract View Poster | ||
| Brecht, Andreas | ||
| Cellular Protein Dynamics Studied With Covalently Labeling Protein Tags View Abstract | ||
| Briggs, Michael | ||
| Hepatocyte Culture Performance is Improved Over Current Methods When Cells are Grown On A Synthetic ECM-Mimetic Surface Topography View Abstract | ||
| Brown, Jason | ||
| Development of Label Free Cellular Assays Using Primary Neuronal Cells View Abstract | ||
| Carlson, Coby | ||
| Advances in HTS Methods for Interrogation of the PI3K/Akt/mTOR Pathway View Abstract View Poster | ||
| Carter, Alison | ||
| Direct Fluorescent Labelling Approaches for G-protein Coupled Receptors & Imaging Using the Opera™ High-Content Screening Platform View Abstract View Poster | ||
| Chan, Leo | ||
| A General Method for Discovering Inhibitors of Protein-DNA Interactions Using Photonic Crystal Biosensors View Abstract | ||
| Chen, Kevin | ||
| Automation of Pre-coated PAMPA Plates Improves Predictability, Reproducibility, & Efficiency View Abstract | ||
| Cheng, Hung-Yuan | ||
| ExpressLC – A Platform For Fast, Reliable Separation-Based Assays Using Microflow LC Separations & Nanoliter Volume Detection View Abstract | ||
| Cheo, David | ||
| Navigating the High-content Imaging Process View Abstract | ||
| Chiou, William | ||
| Rapid Improvement of Protein Stability by Thermal Profiling View Abstract | ||
| Chol Kang, Hee | ||
| Novel Ratiometric Phospholipase A2 Specific Enzyme Substrate with a Fluorescence Donor & Acceptor Pair View Abstract | ||
| Clark, Jonathan | ||
| Further Characterization of BIRB0796 using Multiple Target Class Profiling View Abstract | ||
| Clarke, Scott | ||
| High-Throughput Assays for de novo DNA Synthesis using Click Chemistry Detection Technology View Abstract | ||
| Cloutier, Tim | ||
| Dual Purpose Cell Lines for Analysis of GPCR/Arrestin Interaction Using PathHunter & Natural Gq-coupling Using the Improved Calcium No-Wash PLUS Kit. View Abstract | ||
| Cohen, Seth | ||
| Phosphodiesterases A Novel Microfluidic Mobility-Shift Assay for Inhibitor Screening & Profiling View Abstract | ||
| Cong, Mei | ||
| One Stop Total Cell-Based Assay Solution with Invitrogen From Assay Validation to High-Throughput Screening in Few Weeks View Abstract | ||
| Cook, Lynda | ||
| Increasing Efficiency & Maintaining Quality Running HTS on a 24/7 Schedule. View Abstract | ||
| Crittenden, Carole | ||
| Evaluation of AequoZen™ Frozen Cells Starter Kit using the Aequorin Option for the FLIPR TETRA® System View Abstract | ||
| Cromwell, Evan | ||
| High-throughput DNA Damage Assay for Breast Cancer Related Protein Markers using the IsoCyte™ Platform View Abstract | ||
| Dahan, Sophie | ||
| Automation & Miniaturization of Immunoassays for Drug Discovery AlphaLISA®, a Sensitive No-Wash Assay View Abstract View Poster | ||
| Damon, Presenter | ||
| Frozen Human Primary Cells for High-Throughput Screening View Abstract View Poster | ||
| Davies, Ian | ||
| Quantitative Analysis of Angiogenesis & Cytoskeletal Formation with IN Cell Investigator View Abstract View Poster | ||
| Davies, June | ||
| Imaging PML Nuclear Bodies Using a High-content Imaging Platform View Abstract View Poster | ||
| Dawson, Jack | ||
| An Integrated Solution for Efficient Enzyme Panel Screening View Abstract | ||
| Days, Emily | ||
| Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor 8 (mGluR8) using GIRK-mediated Thallium Flux Modulation in High-Throughput Screening View Abstract View Poster | ||
| De Visscher, Geofrey | ||
| Bioactive Coatings For Stem Cell Homing & Its Applications In Heart Valve Tissue Engineering View Abstract | ||
| DeChard, Collette | ||
| The Great Transfer View Abstract | ||
| Degorce, Francoise | ||
| HTRF® Deacetylation Assay A new solution for HDAC/SIRT Screening View Abstract | ||
| HTRF® Transcreener™ ADP Assay The New Solution for ADP Detection View Abstract | ||
| Dell, EJ | ||
| Old Assays, New Instrument The Omega - High Speed, UV/Vis Spectrometer in a Microplate Reader View Abstract | ||
| Diwu, Zhenjun | ||
| A New Robust No-Wash FLIPR Calcium Assay Kit for Screening GPCR & Calcium Channel Targets View Abstract View Poster | ||
| Doranz, Benjamin | ||
| Atomic-level Structural & Kinetic Analysis of Integral Membrane Protein Binding Interactions View Abstract | ||
| Dull, Angie | ||
| Screening for Estrogen Receptor á (ERá) Ligands Using Nuclear Translocation Analysis View Abstract | ||
| Elkin, Lisa | ||
| Strategies for Improving the Impact of High-Throughput Screening Campaigns View Abstract View Poster | ||
| Ellen, Mary | ||
| Leveraging Early Liability & Drug Safety Assessment by Integration of Innovative Screening Automation, High-Throughput Reagent Generation & Novel Bioassay Technology View Abstract | ||
| Emans, Neil | ||
| Sub-Cellular Resolution Genome Wide RNA Interference Analysis Within A Day View Abstract View Poster | ||
| Esterman, Abbie | ||
| Kinase Inhibitor Profiling & Compound Characterization on a Microfluidic Mobility-Shift Platform View Abstract | ||
| Evans, Kenda | ||
| New Aequorin Parental Cell Lines for Screening of GPCRs View Abstract View Poster | ||
| Fang, Jack | ||
| Detection of Ligand-Dependent Interaction of Nuclear Receptors with their Cofactor Using the Corning® Epic® System View Abstract | ||
| Fang, Ye | ||
| Label-Free Optical Biosensor for Probing Receptor Biology Theory, Modeling & Applications View Abstract | ||
| Fayez, Husam | ||
| Maintaining the Integrity of the Wyeth Liquid Samples View Abstract | ||
| Fecke, Wolfgang | ||
| Identification of Novel Therapeutics for Treatment of Huntington’s Disease – a Phenotypic Screening Cascade View Abstract View Poster | ||
| Ferrie, Ann | ||
| Label-Free Optical Biosensor for Probing GPCR Ligand-Directed Functional Selectivity View Abstract | ||
| Fitzgerald, Kate | ||
| Differential Cell Adhesion Within An Isogenic Model Of Melanoma Progression Under Shear Flow Conditions Using Cellix’s Venafluxtm Platform View Abstract | ||
| Flores, Sandra | ||
| Aequorin Plasmids A Novel Tool for Generating Cell Lines for Luminescence Assays View Abstract View Poster | ||
| Freeman, Adrian | ||
| Applying The Labcyte MicroClime Lid In Biological Assays To Improve Data Quality & Quantity. View Abstract | ||
| Galkin, Anna | ||
| Permeability Studies Of Coumarins With New Modified Caco-2 Cell Model View Abstract | ||
| Gallagher, Aoife | ||
| High-Throughput Kinase Selectivity Profiling for Drug Discovery Applications View Abstract | ||
| Gallant, Debra | ||
| The CellKey™384 System Enables High-Throughput Screening with a Label-free Cell-Based Assay Platform. View Abstract | ||
| Gan, Qing-Fen | ||
| An Ion Channel FLIPR HTS Using the New Fluo-8 Calcium Dye View Abstract View Poster | ||
| Gao, Lin | ||
| Ru TR-FRET Assays Evaluation of Two Acceptor Dyes & Comparison with Eu TR-FRET Assays View Abstract | ||
| Gao, Yi | ||
| Biochemical Assays for Selectivity Profiling Across the Entire PI3 Kinase Family View Abstract | ||
| Garcia, Khristofer | ||
| Profiling the Activity of Proteasome Inhibitors Using Promega’s Proteasome-Glo™ Cell-Based Assay View Abstract | ||
| Gasser, Michele | ||
| Successful Implementation of a Bio-Sample Store View Abstract View Poster | ||
| Ghosh, Richik | ||
| Assessment of PI3-Kinase & AKT Signaling Using Quantitative Cell-Based Immunofluorescence High-content Screening Assays View Abstract View Poster | ||
| Giannetti, Anthony | ||
| A Surface Plasmon Resonance Based Assay for the Detection & Characterization of Promiscuous Inhibitors View Abstract | ||
| Gill, Sikander | ||
| PCR Set Up in LightCycler® Carousels Using VERSA Workstations View Abstract View Poster | ||
| Gopalakrishnan, Sujatha | ||
| Functional Characterization of Positive Allosteric Modulators of a7 Nicotinic Acetylcholine Receptors in IMR-32 Neuroblastoma Cells View Abstract View Poster | ||
| Goti, Sejal | ||
| HistopatholgicalSpectrum of Thymic Neoplasms Nine-years Research Survey at a SAL Hospital, Ahmedabad, India View Abstract | ||
| Graves, Pierre | ||
| Antibody-free Lck Kinase Fluorescence Lifetime Assay View Abstract View Poster | ||
| Green, Andrew | ||
| Screening of a Kinase Enzyme Utilizing IMAP Assay & EnVision Multi-format Plate Reader Technologies. View Abstract View Poster | ||
| Gualtieri, Giovanna | ||
| PhotoScreen™ luminescent Calcium Assays Applications on LumiLux® & FLIPRTETRA® View Abstract | ||
| Guedat, Philippe | ||
| From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction through the HIV-1 Integrase / human LEDGF-Case Study. View Abstract | ||
| Hang Mak, Lok | ||
| Drug-Drug Interactions of Human Cytochrome P450s by a New Electrochemical Array View Abstract | ||
| Hanson, Bonnie | ||
| Taming the EDG Receptor Family with the Tango™ Technology View Abstract | ||
| Harding, Heather | ||
| Optimizing Nucleic Acid Detection by Altering Detection Chemistry View Abstract View Poster | ||
| Harings, Kathy | ||
| A Multiplex Approach to Characterization of RTK & ERK Pathway Signaling View Abstract | ||
| Härmä, Harri | ||
| A Sensitive & Simple Homogeneous QRET Technology for Biomolecular Screening View Abstract | ||
| Harrington, Bob | ||
| Beyond Kinases Interrogating the Purinome View Abstract | ||
| Hayes, Steve | ||
| Microchannel Assays Using Primary Tumor Cells, Co-culture & 3-dimensional Extracellular Matrices View Abstract | ||
| He, Jianjun | ||
| Selective Detection of Pyrophosphate Using a Fluorogenic Pyrophosphate Sensor View Abstract | ||
| Heimann, Andrea | ||
| A New Technology for G-protein Coupled Receptors Analysis Conformational Specific Antibodies. View Abstract View Poster | ||
| Held, Paul | ||
| The Synergy Family of Readers, A Lower Cost High Performance Alternative for Running AlphaScreen Assays View Abstract View Poster | ||
| Heller, Rainer | ||
| Development of a Non Binding Surface for Biochemical Assays & High-Throughput Screening View Abstract View Poster | ||
| Hesley, Jayne | ||
| High-Throughput Cell Migration Assay with the IsoCyte™ Laser Scanning Platform View Abstract View Poster | ||
| Heyerdahl, Sarah | ||
| Dimerization of BZIP Proteins in Living Cells Assayed by Fluorescence Imaging Technology View Abstract | ||
| Hisada, Sunao | ||
| Hamamatsu Photonic FDSS7000 The New uHTS System with Multi-Dispense & Multi-Detection mode. View Abstract | ||
| Holskin, Beverly | ||
| An Aequorin Luminescence-Based Assay for Monitoring GPCR Function in Cryopreserved CHO Cells Transiently Expressing Either a Receptor-of-Interest or Apo-aequorin-3 View Abstract | ||
| Hong, Suk | ||
| Predictive Cytotoxicity Measurements by Monitoring Heat Shock Proteins & the Cell Cycle in High-content Screening Cell-Based Assays View Abstract View Poster | ||
| Houck, Keith | ||
| In vitroToxicity Screening by Transcription Factor Activity Profiling View Abstract | ||
| Houtman, Rene | ||
| PamChip Peptide Micro Array Technology Applications in Kinase & Nuclear Receptor Research View Abstract | ||
| Howland, Sara | ||
| Development of Customized Immunoassays using AlphaLISA® View Abstract View Poster | ||
| Hoyle, Christopher | ||
| nanoCF™ Assay system A Novel Tool for Mechanistic Studies Part Two Compound Profiling & Mechanism of Action View Abstract | ||
| Hsu, Matthew | ||
| Validation of Different Aequorin Mutants for GPCR Screening Using the FLIPRTETRA® System with Aequorin Option View Abstract | ||
| Huggins, Cerys | ||
| Comparison of Photina® Luminescent Calcium Mobilization Assays on both the FlexStation 3® & the FLIPRTETRA® Systems View Abstract | ||
| Hughes, Bethany | ||
| Comparison of An Alphalisa Assay vs. ECL & ELISA Assays to Measure Abeta40 & Abeta42 Levels for HTS & Lead Optimization View Abstract | ||
| Hull, Carl | ||
| Processware - An Order of Magnitude Improvement in LIMS Technology View Abstract View Poster | ||
| Ines Morano, Maria | ||
| High-Density STEP Array Plates A Novel Platform for Multiplexed GPCR Screening View Abstract | ||
| Ionescu, Cristian | ||
| An Automated Microfluidic Dose-Response System for Ion Channels View Abstract | ||
| Ismail, Rahman | ||
| The Application of Microcarrier Technology to The Provision of Receptor Membranes For High-Throughput Screening View Abstract | ||
| Jackson, Laura | ||
| Stem Cell-Derived Neurons In CNS Drug Discovery View Abstract | ||
| Jacob, Renju | ||
| M-Screen An Open-Source, Web-Based Application Package that Integrates Compound Management & High-Throughput Screening (HTS) Data Analysis View Abstract | ||
| Jahla, Manisha | ||
| Use of PocketTip for Both Compound Storage & Screening View Abstract | ||
| James, Presenter | ||
| High-content Screening Enables High-Throughput Screening View Abstract | ||
| Jamieson, Bruce | ||
| Best Practices for Assessing Nanoliter Transfer Performance for Acoustic Droplet Ejection Liquid H&lers View Abstract | ||
| Janssen, Richard | ||
| Drug Target Discovery In Huntington Disease Cell Death Modifiers Identified With Adenoviral Shrna Technology View Abstract | ||
| Jenkins, Joby | ||
| Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution using mosquito ® View Abstract | ||
| Johnston, Paul | ||
| Screening the NIH’s Compound Library to Identify Inhibitor Probes of Human Immunodeficiency Virus Reverse Transcriptase-associated Ribonuclease H Activity. View Abstract | ||
| Jonker, Niels | ||
| Dynamic Protein Affinity Chromatography SPE-LC-MS Finding New Receptor Ligands in Complex Mixtures View Abstract | ||
| Jonsson, Colleen | ||
| Addressing the Tractability of Difficult Viral Targets Approaches Toward the Discovery of Antivirals for Lethal RNA Viruses that Require Biocontainment View Abstract | ||
| Kabous, Laila | ||
| Beyond Biomolecular Screening A Multi-Parametric Procedure for Efficient Hit & Lead Identification View Abstract | ||
| Karaman, Mazen | ||
| A Quantitative Analysis of Kinase Inhibitor Selectivity View Abstract | ||
| Karhunen, Ulla | ||
| Homogeneous Time-Resolved Fluorescence-Based Assay for Phosphorylated Peptides Using a Generic Binder View Abstract | ||
| Kauffman, Jack | ||
| Comparison of Aequorin to Flourescent Dye for GPCR Calcium Flux Using Cells Transfected With The Human Free Fatty Acid (FFA1) Receptor (GPR40). View Abstract View Poster | ||
| Kellard, Libby | ||
| An Automated Method for the Expansion & Neural Differentiation of Embryonic Stem Cells View Abstract View Poster | ||
| Kemmerer, Amanda | ||
| Utilizing Techniques in Developing & Optimizing Assay Paradigms to Increase Throughput in Screening Small Libraries & Special Compound Collections View Abstract | ||
| Kendall, Bob | ||
| Cell Factory. Production of cryopreserved cells as reagents for screening assays. View Abstract | ||
| Kettleborough, Catherine | ||
| MRC Technology’s Drug Discovery Group; a Mechanism for De-risking Novel Targets Emerging from Academia. View Abstract | ||
| Khanna, Pyare | ||
| PathHunter™ Protein Interaction Assays for Analysis of Receptor Kinase Dimerization in Whole Cells. View Abstract | ||
| Kim, Namyong | ||
| Slide-based Miniaturized Microtiter Plate for ELISA & Cell-based Assays View Abstract View Poster | ||
| Kleman-Leyer, Karen | ||
| GDP Detection Using the Transcreener Technology View Abstract | ||
| Klotzsche, Oliver | ||
| Frozen Cells in Assay Plates for Instant Use in Cell-Based Screening View Abstract View Poster | ||
| Kodoyianni, Voula | ||
| SPR Imaging, a Label-Free Method for the Analysis of Microarrays View Abstract View Poster | ||
| Komoriya, Akira | ||
| Cell-Permeable Fluorogenic Oligonucleotides Single Cell RNA Profiling, Antisense & siRNA Delivery, & Live Cell Imaging View Abstract View Poster | ||
| Kool, Jeroen | ||
| Simultaneous on-line bioaffinity screening and identity characterization of metabolic mixtures for fast and comprehensive metabolic profiling View Poster | ||
| Kraybill, Brian | ||
| Development of an Automated AlphaScreen for Detection of MEK Phosphorylation in a Transiently Transfected Cellular Model View Abstract | ||
| Krell, Hans-Willi | ||
| FMAT Based Assay to Detect Antibodies Against Cell Surface Receptors View Abstract | ||
| Kuchibhatla, Sailaja | ||
| An Optimized ADP Accumulation Assay For PI3 Kinase Primary Screening & Inhibitor Characterization View Abstract | ||
| Kurchii, Bogdan | ||
| What Structural Features Explain why Some Fragments of the Molecule are Important While Others are not? View Abstract | ||
| Lacaille, Vashti | ||
| Utilization of PathHunter Arrestin Cell Lines for Detection of Arrestin Biased Ligands & Compound Pharmacology Distinct from Second Messengers. View Abstract | ||
| Larsen, Martha | ||
| Complementary Cell-Based Screens Identify Specific Inhibitors of the Unfolded Protein Response Apoptotic Sub-Pathway and Reduce False Positive Hits View Abstract | ||
| Larson, Brad | ||
| Optimizing Performance of the Transcreener™ ADP Assay for Commonly Used Multiwell Readers View Abstract | ||
| Lea, Wendy | ||
| A 1536-well Based AlphaScreen Assay for Tdp1 Inhibitor Identification View Abstract | ||
| Lee, James | ||
| Automatic Recptor Trafficking Assay Analysis using Machine Learning View Abstract | ||
| Lee, Paul | ||
| Identification of GPR23 Agonists, Antagonists & Inverse Agonists by High-throughput Screening View Abstract | ||
| Lee, Sunghou | ||
| High-Throughput Screening of HAUSP Inhibitors Using the TR-FRET Based DUB Substrate View Abstract | ||
| Lehmann, Werner | ||
| Immobilized Bead Assay System For Multiple Analyte Detection View Abstract | ||
| LeRoy, Didier | ||
| Antimalarial Drug Discovery From Target Validation to Lead Qualification View Abstract | ||
| Levy, Vered | ||
| Intracellular Nitric Oxide (NO) Generation Rates Correlate With Different No Synthases’ Expression Levels, At The Resolution of Individual Living Cells View Abstract | ||
| Li, Xiao | ||
| Improvements in GPCR & calcium channel screening using Second Generation BD Calcium Assay Kits View Abstract | ||
| Liao, Jinfang | ||
| Quest Rhod-4™ Calcium Indicator, a New Red Fluorescent for Screening GPCR & Calcium Channel Targets View Abstract | ||
| Lightbody, Brian | ||
| The use of Isothrmal Titration Calorimetry to Determine Enzyme Kinetic Constants for PP1-gamma Phosphatase View Abstract | ||
| Lin, Wenwei | ||
| Development of a Novel High-Throughput Screening Assay to Identify both Agonist/potentiator & Antagonist of Pregnane X Receptor (PXR) View Abstract | ||
| Liu, Ke | ||
| A Functional Assay for Gq-coupled GPCRs by Measuring Inositol Monophospate-1 in 1536-well Plate format View Abstract | ||
| Liu, Li | ||
| Automated Low Volume Cell Dispensing & Analysis Using the BioRAPTR FRD Microfluidic Workstation & PARADIGM™ Detection Platform for cAMP & Ion Channel Assays View Abstract | ||
| Lowery, Robert | ||
| Application of the Transcreener™ AMP/GMP Assay for Interrogating Ubiquitinylation Cascades View Abstract | ||
| Lu, Jianming | ||
| A New Fluorescent Mitochondrial Membrane Potential Sensor for Imaging & Fluorescence Plate Reader-Based Applications View Abstract | ||
| Lu, Quinn | ||
| Production of Biologically Active Chemokines In E. Coli View Abstract View Poster | ||
| Lunn, Charles | ||
| Antagonizing mPGES-1 Developing a High-Throughput Screening Assay View Abstract | ||
| Lygren, Birgitte | ||
| AKAP18 - A Potential Drug Target in Heart Failure Patients? View Abstract | ||
| Ma, Haiching | ||
| Chemical-Kinomic Approach to Analyze the Selectivity of Kinase Inhibitors View Abstract | ||
| Maher, Julio | ||
| A new Paradigm in Sample Library Management & Replication View Abstract View Poster | ||
| Mandavilli, Bhaskar | ||
| The Use of Quantitative, Cell-based, High-Content Screening Assays to Detect In vitro Genotoxicity & the Effect on Cell Cycle Checkpoints View Abstract View Poster | ||
| Mann, Christopher | ||
| Rapid Selective In Situ Screening Of Hybridomas in Semisolid Medium View Abstract View Poster | ||
| Martin, John | ||
| HIF-Prolyl Hydroxylase; Preparation of Multiple Reagents to Develop TR-FRET Assay for HTS View Abstract | ||
| Masse, Frederic | ||
| Screening against Proteases Comparison of QFRET Substrates & Miniaturization of a Plasma Protein Shift Assay View Abstract View Poster | ||
| Matico, Rosalie | ||
| Purification & Enzymatic Characterization of Recombinant ADAMTS-5 in Aggrecan based MSD Assay View Abstract | ||
| Mattoon, Dawn | ||
| Compound Selectivity & Specificity Profiling Using Functional Protein Microarrays View Abstract | ||
| Mazzarese, Florence | ||
| Improving the efficiency of 384 “mini-tube” Technology Using Mosquito® nanolitre pipetting View Abstract | ||
| Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution Using mosquito ® View Abstract | ||
| Mika, Justin | ||
| Profiling for GPCR activation using DiscoveRx PathHunter B-Arrestin Technology View Abstract | ||
| Miller, Jane | ||
| Improvements in Data Quality & Assay Performance Using Aequorin for Calcium Based Screening. View Abstract | ||
| Miraglia, Loren | ||
| Advances in Genomic Screening Through High-Throughput Viral Production View Abstract View Poster | ||
| Mirjalili, Noushin | ||
| Use of a High-Throughput Phosphodiesterase Profiling Platform to Study Inhibitors Selectivity View Abstract | ||
| Morgan, Heidi | ||
| Steady State Characterization of Death Associated Protein Kinase 1 Using Microfluidic Technology View Abstract View Poster | ||
| Mosser, Scott | ||
| Facing the Challenges of Supplying Assay Ready Plates Utilizing Special Library Sets to Obtain Novel Leads for the Hit to Lead Phase of Drug Discovery View Abstract | ||
| Muller-Kahle, Hans | ||
| Identification of MMP-12 Inhibitors by a Biosensor-Based Screening of a Fragment Library View Abstract View Poster | ||
| Murphy, Steven | ||
| Division Arrested Cells Simplifying Assay Design & Increasing Flexibility View Abstract View Poster | ||
| Nelson, Sandra | ||
| Three Kinase Screening Assays Using a Generic ADP Detection Method View Abstract View Poster | ||
| Neumann, Ken | ||
| An AlphaLISA® Workstation – A Complete Solution for Immunoassay Simplification, Improved Performance, Maximized Throughput, Increased Sensitivity, & Assay Cost Reduction View Abstract View Poster | ||
| Newsome, III, William | ||
| ADPHunter™ Plus Extended Application for Detection of GDP & UDP Production View Abstract | ||
| Niles, Walter | ||
| Cyclic Olefin Polymer is a Superior Material For High-Density Multiwell Microtiter Plate Construction View Abstract | ||
| Oh, Seho | ||
| Robust Kinetic Characterization of Moving Objects for Subcellular Time-lapse Assays View Abstract | ||
| Oinonen, Päivi | ||
| Screening of Antimicrobial Compounds in Fungal Extracts against Gram-positive & Gram-negative Bacteria View Abstract | ||
| Oldenburg, Kevin | ||
| A New Aquesous Solubility Screen High-Throughput Sonication View Abstract View Poster | ||
| Olechno, Joe | ||
| High-Throughput Secondary Screening—1400 Dose-Response Curves per Hour View Abstract | ||
| Olsen, Cathy | ||
| Multiplexing Fluorescent & Chemiluminescent Live Cell Reporters to Dissect NFkB Signal Transduction Requirements View Abstract | ||
| Olson, Keith | ||
| GPCR Screening and Profiling Using Arrestin Reveals Unique Pharmacology for Compounds on Known Receptors and Provides a Platform For Oprhan GPCRs in Discovery and Repositioning Applications View Abstract | ||
| Opperman, Kay | ||
| Quantitative High-Content Analysis of Intracellular Oxidative Stress & DNA Damage View Abstract View Poster | ||
| Padfield, Dirk | ||
| Spatio-Temporal Cell Segmentation & Tracking for Automated Screening View Abstract View Poster | ||
| Padros, Jaime | ||
| Development of COT, mTOR & NEK6 Kinase Assays Using the LANCE® Ultra ULight™-p70 S6K (Thr389) Peptide View Abstract View Poster | ||
| Paes, Cheryl | ||
| Structural Mapping Of Gpcr Interactions With Ligands, Drugs, & Antibodies View Abstract | ||
| Panagiotakakos, Athena | ||
| Use of IMAP TR-FRET Detection Mode for the IMAP AGC & CAMK Group Substrate Finder View Abstract | ||
| Pandey, Pramod | ||
| Application of plex-in-plex Branched DNA Assay in Quantitating mRNA in Early Drug Discovery View Abstract | ||
| Parent, Stephane | ||
| Development of 8 New No-Wash Immunoassay Kits for the Detection of VEGF, Amyloid Beta1-40, Amyloid Beta1-42, Insulin, Human IgG, EPO, HIV p24 & TNFalpha Using PerkinElmer AlphaLISA View Abstract View Poster | ||
| Payne, Sarah | ||
| High-content Image Analysis Using a Laser Scanning Microplate Cytometer View Abstract | ||
| Peach, Matthew | ||
| Detection of Caspase-3/7 Activity in Human Serum & Plasma as a Potential Biomarker of Apoptotic Cell Death Using the Promega Caspase-Glo® 3/7 Assay View Abstract | ||
| Peng, Xinzhan | ||
| A Novel Non-Fluorescent Quencher Dye Quenching a Broad Range of Fluorophores & Its Implementation in Protease Activity Assays View Abstract | ||
| Pfeifer, Lutz | ||
| Duplex HTS Assay Measured Simultaneously With Nano-TRF & fluorescence Lifetime Method View Abstract View Poster | ||
| Piazza, Gary | ||
| The Southern Research Molecular Libraries Screening Center View Abstract | ||
| Pihl, Johan | ||
| Electroporation-based System for Genome Wide RNAi Screening View Abstract | ||
| Pineau, Robert | ||
| A Story in Method Transfer Troubleshooting Accuracy Matters When Transferring Quantitative, Manually-pipetted Assays to Automation View Abstract | ||
| Piper, David | ||
| Building the Predictor™ Fluorescence Polarization Assay for High-Throughput Screening of hERG Channel Affinity View Abstract | ||
| Piu, Fabrice | ||
| Receptor Selection & Amplification Technology A Unique, Powerful Screening Platform for Drug Discovery View Abstract | ||
| Piwnica, David | ||
| Establishment of Functional Assays that Discriminate Between Neutral Antagonists & Inverse agonists View Abstract | ||
| Plater, Andrew | ||
| HTRF as a Reliable Platform for Large Scale Kinase Profiling View Abstract | ||
| Po, Cecilia | ||
| A Novel Fluorimetric Assay for Detection of TACE (Ą-secretase) Activity Using a Long Wavelength FRET Peptide Substrate View Abstract | ||
| Poon, Grace | ||
| A High-Throughput Permeability Screening Methodology Utilizing a Novel Artificial PAMPA Membrane & LC/MS/MS Detection View Abstract | ||
| Poore, Derek | ||
| Development of a High-Throughput LanthaScreen Assay for DNA-dependent Protein Kinase View Abstract | ||
| Proctor, John | ||
| Introducing the CellKey™384 System, A Label-Free High-Throughput Cell-Based Assay for Functional Screening of Cellular Receptors View Abstract | ||
| Qian, Ting | ||
| Screening & Development of Antibodies For Use in High-content Immunofluorescent Microscopy. View Abstract | ||
| Raduazo, Rocco | ||
| Development of a Panel of cAMP Hunter™ Cell Lines for Analysis of Naturally Coupled GPCRs Using the DiscoveRx HitHunter™ cAMP Detection Kits. View Abstract | ||
| Rainville, Paul | ||
| A Rapid Assay for p450 Inhibition/Induction Utilizing Ultra Performance Liquid Chromatography & Tandem Quadrupole Mass Spectrometry View Abstract | ||
| Raitio, Marika | ||
| Performing Cytotoxicity Assays with Sleeping Cells & Thermo Scientific Microplate Readers View Abstract | ||
| Randle, David | ||
| Label-Free Cell-Based Screening for GPCR Agonists & Antagonists using the Corning® Epic® System View Abstract | ||
| Reddy, Lakshmi | ||
| Human Anti-Angiogenesis High-Throughput Screening Assay in 384-Well Format View Abstract View Poster | ||
| Redpath, Stella | ||
| CellCiphr – Cellular Systems Biology Assay for Hepatotoxicity Using Human HepG2 Cells View Abstract | ||
| Retra, Kim | ||
| Using Surface Plasmon Resonance & the Acetylcholine Binding Protein to Screen for Ligands for the Nicotinic Acetylcholine Receptor View Abstract | ||
| Reznik, Gary | ||
| Full Automation of Magnetic Bead-Based Luminex xMAP Cytokine Assays on the PerkinElmer JANUS® Automated Liquid Handling Platform View Abstract View Poster | ||
| Roncinske, Rick | ||
| An RGS protein HTS assay Strategy using the Transcreener™ GDP Assay View Abstract | ||
| Rothenberg, Mark | ||
| Maintaining 1536 Well Assay-Ready Microplate Reagent Integrity Using An Automatable Microplate Lid That Provides An Environmental Barrier Seal View Abstract | ||
| Russell, Rachel | ||
| Creative Ways to Increase our Screening Capacity in a Production Environment. View Abstract View Poster | ||
| Safa, Parsa | ||
| Use of IMAP TR-FRET Detection Mode for the IMAP Tyrosine Kinase Group Substrate Finder View Abstract | ||
| Sanghera, Jas | ||
| A High-content Homogeneous Assay for P-Glycoprotein Inhibition using Microplate Cytometry View Abstract | ||
| Santos, Mark | ||
| Unveiling Drug Selectivity Via Functional Profiling & Multi-Prong Approach To Hit Validation Using ChemiScreen™ GPCR Cell Lines View Abstract View Poster | ||
| Scarabottolo, Lia | ||
| Application of the Calcium-Sensitive Reporter Photina® to Generate HTS Assays for Na/Ca2+ Exchangers. View Abstract | ||
| Schaub, Theresa | ||
| PathHunter™ NHR Protein Interaction Cell Lines Study Nuclear Hormone Receptors Without Using Reporter Gene Assays View Abstract | ||
| Schenker, Ben | ||
| A Modular Solution For Long Term Storage of Biological Samples View Abstract | ||
| Schultz, Jan | ||
| The Use of QuickZyme™ for the Identification of Novel Inhibitors of Anthrax Lethal Factor We Report On Our Efforts Using the QuickZyme™ Technology Platform for the Identification of Novel Inhibitors of Anthrax Lethal Factor (ALF) View Abstract View Poster | ||
| Schwab, Markus | ||
| Watchmaker® - Compound Generation by Combinatorial Genetics & Screening in Yeast View Abstract View Poster | ||
| Schwartz, Benjamin | ||
| Development of a Plasma Based Assay for Endothelial Lipase View Abstract | ||
| Scibek, Jeffery | ||
| Label-Free Antibody Screening Sandwich Assay Using the Corning Epic® System View Abstract | ||
| Shanler, Michael | ||
| Validation of Automated High-Throughput Plasma Protein Binding Assays View Abstract | ||
| Sharlow, Elizabeth | ||
| Interrogation of the National Institutes of Health Small Molecule Repository for Protein Kinase D Inhibitors View Abstract | ||
| Shave, Darcy | ||
| An Automated LC/MS/MS Protocol To Enhance Throughput of Physico-Chemical Property Profiling In Drug Discovery View Abstract | ||
| Sheard, Simon | ||
| Storage Solutions New Technologies, New Applications View Abstract | ||
| Shieh, Jean | ||
| Kinase Assay Development Using Acoustic Droplet Ejection Technology View Abstract | ||
| Shrout, Anthony | ||
| Template-Directed Self-Assembly Imparts Biological Relevance to Standard In vitro Assays View Abstract | ||
| Shultz, Sarah | ||
| Luminescent Assay Optimization, Kinase Profiling, & uHTS Application View Abstract View Poster | ||
| Sieg, David | ||
| LipoSignal A Homogeneous, Cell-Free Assay for Screening for Modulators of GPCR Activation View Abstract | ||
| Singh, Rajendra | ||
| Kinase Selectivity Profiling on EZ Reader™ – 144 Kinases Against 12 Compounds in a Day. View Abstract | ||
| Sklar, Larry | ||
| HTS Flow Cytometry of Multiplexed Targets HTS Flow Cytometry View Abstract | ||
| Skoien, Allyson | ||
| A Heterogeneous Angiogenesis Assay Using Primary Cell Co-Culture In Microchannels View Abstract View Poster | ||
| Soni, Deena | ||
| A Genome-wide siRNA Screen for Identifying Novel Genes Involved in Maintaining Genomic Stability View Abstract | ||
| Sörensen, Per | ||
| Advances in Automated Transporter Screening Parallelization Approach leads to Eight-Fold Increase in Throughput View Abstract View Poster | ||
| Sosa, Melinda | ||
| Data Processing & Quality Assurance in a Kinetic Enzyme Assay View Abstract View Poster | ||
| Stark, Diane | ||
| A Bioactivity Screen to Identify Novel Toll-Like Receptor Peptide Agonists for Use as Vaccine Adjuvants View Abstract | ||
| Suzuki, Melissa | ||
| Tools & Processes to Drive Data Quality & Throughput for Biochemical & Cellular Compound Profiling View Abstract View Poster | ||
| Swaffield, Jonathan | ||
| Integration of a Labcyte Echo 550 Liquid Handler® with a Velocity 11 Element System™ View Abstract | ||
| Szymanski, Stacey | ||
| A New Approach to Cell-Based Assays Mouse Embryonic Neural Stem Cells View Abstract | ||
| Tafelmeyer, Petra | ||
| From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction Through the HIV-1 Integrase / LEDGF-Case Study View Abstract | ||
| Talvitie, Miika | ||
| Evaluation of the New EnVision Monochromator Option View Abstract View Poster | ||
| Tanega, Cordelle | ||
| A Quantitative High-Throughput Screen for LMNA Splicing Modulators View Abstract | ||
| Tang, Weimin | ||
| Identification of Cytochrome P450 Mechanism-Based Inhibitors Using In vitro High-Throughput Assay View Abstract | ||
| Tarassishin, Leonid | ||
| A Kinase Focused RNAi Screen Identifies Novel Mediators of Apoptosis View Abstract | ||
| Tardieu, Jean-Luc | ||
| Determination of a Galpha/i-coupled Receptor Activity Using CISBIO’s Membrane-based cAMP HiRange® kit View Abstract | ||
| Thomas, Robbie | ||
| High-Throughput Fluorescence Lifetime Based Assays for Protein Kinases View Abstract | ||
| Thorne, Natasha | ||
| Targeting & manipulating the STAT, M1-NFAT, & NFêB signaling pathways in quantitative high-throughput screening (qHTS) using a laser-scanning fluorescence microplate cytometer View Abstract | ||
| Tian, Yang | ||
| High-throughput Screening Identifies Novel Inhibitors for Bacillus Anthracis O-succinylbenzoyl-CoA Synthetase View Abstract | ||
| Tierney, Brenda | ||
| KingFisher® Flex – Flexible Automated Nucleic Acid, Protein & Cell Purification View Abstract | ||
| Towne, Danli | ||
| Application of HCS Technology to Detect Receptor Internalization to Identify Selective CB2 Receptor Agonists View Poster | ||
| Tran, Elizabeth | ||
| Label-Free Optical Biosensor for Probing the Roles of Adenylate Cyclases in Signaling Integration of G Protein-Coupled Receptors View Abstract | ||
| Trinquet, Eric | ||
| Introduction of a new TR-FRET Terbium Cryptate IP-One Tb, a new generation HTRF® kit applied to GPCR Screening & Investigation View Abstract | ||
| Vattem, Krishna | ||
| The Use of Multi-Parametric High-Content Screening Assays to Monitor Cytotoxicity & Different Programmed Cell Death Pathways. View Abstract View Poster | ||
| Veith, Henrike | ||
| Distribution of Cytochrome P450 Activity Across Known Drugs & Diverse Compound Collections View Abstract | ||
| Ver Donck, Kris | ||
| Brightfield as a Label Free Adjunct to Fluorescence High-content Screening for Improved Assay Performance & Data Quality View Abstract View Poster | ||
| Vernetti, Lawrence | ||
| Application of Cellular Systems Biology to Cytotoxicity Profiling View Abstract | ||
| Vian Tan, Eu | ||
| Label Free Holographic Biosensors for Drug Discovery View Abstract | ||
| Wai, Yeung | ||
| An Assessment of Multiple Fluorescence Calcium Indicator Dyes in Three Diverse Recombinant Systems By Measurement in A Flipr Cell-Based Calcium Flux Assay View Abstract | ||
| Walmsley, Richard | ||
| Stratgies to Reduce the Number of True Genotoxins Proceeding to Animal Testing View Abstract | ||
| Wang, Yanli | ||
| Mining Biological Screening Data in PubChem View Abstract | ||
| Wartchow, Charles | ||
| Label-Free Determination of Kinetic Constants for Small Molecule Binding to Proteins Using FortéBio’s Octet RED Multi-Channel System View Abstract | ||
| Webb, Brian | ||
| Assessment of the Immune Response Using High-content Screening Cell-based Imaging & Antibody Arrays View Abstract | ||
| Wegstein, Jo | ||
| New SA-PE Conjugates Improve Critical Assay Parameters in Sandwich Immunoassays Performed Using Luminex® xMAP® Technology View Abstract View Poster | ||
| Wehrman, Tom | ||
| Miniaturization of the HitHunter™ cAMP XS+ Assay for Gs/Gi Screening in 1536 Well Plate Format. View Abstract | ||
| Wetzel, Randy | ||
| Analysis of Kinase Inhibitors using a Large Array of Signaling Antibodies & High-content Screening. View Abstract View Poster | ||
| Wheatcroft, Russell | ||
| Improving the Efficiency Of 384 “mini-tube” Technology Using Mosquito® Nanolitre Pipetting View Abstract | ||
| Wheeler, Timothy | ||
| High-content Screening Assays for Neurotoxicity Profiling View Abstract | ||
| White, Lucile | ||
| Antituberculosis High-Throughput Dug Screening at Southern Research Institute View Abstract View Poster | ||
| Willis, Sharon | ||
| Biosensor Screening & Analysis of GPCR Interaction Kinetics View Abstract | ||
| Witte, Krista | ||
| Development of the Octet RED System for Label-Free, Multi-channel Kinetic Analysis of Biomolecular Interactions View Abstract View Poster | ||
| Wu, Meng | ||
| Optimization of High-Throughput Ion Channel Screens Using Single Cell & Population Analyses View Abstract | ||
| WU, Xiaohua | ||
| Drug Discovery for Muscular Dystrophies View Abstract View Poster | ||
| Wyrick, David | ||
| nanoCF™ Assay System A Novel Tool for Mechanistic Studies View Abstract | ||
| Xenia Ilagan, Ma | ||
| Screening for Modulators of Notch Signaling using a Luciferase Complementation-Based Reporter View Abstract | ||
| Xia, Qinghua | ||
| Utilizing Nano25 Low Volume Dispenser for Hit Optimization View Abstract | ||
| Xin, Hong | ||
| Application of EpicÒ System in Cell-based Assays View Abstract | ||
| Yamada, Takayuki | ||
| Automated High-Throughput Drug Discovery Using Surface Plasmon Resonance View Abstract | ||
| Yoder, Amy | ||
| High-Throughput Automation of Cisbio’s IP-One HTRF® Assay using the BioRAPTR FRD Microfluidic Workstation & PARADIGM™ Detection Platform View Abstract | ||
| Yuan, Xiu-juan | ||
| Comparison of a Cellular ELISA & AlphaScreen SureFire™ for Evaluation of Ligand Stimulated ERK Phosphorylation in Human Umbilical Vein Endothelial Cells View Abstract | ||
| Zapatero, Cleofe | ||
| Development & Validation of a Protein-Protein Interaction HTS Assay Based on AlphaLisa™ Technology View Abstract | ||
| Zeng, Fu-Yue | ||
| A High-Throughput Screening Assay to Identify Novel Compounds that Differentially Inhibit Cell Proliferation of ARMS & ERMS View Abstract | ||
| Zhai, Yan | ||
| A Novel Incubation Procedure to Reduce Edge-Effect in High-Throughput Cell-Based Assays View Abstract | ||
| Zhang, HaiGuang | ||
| Using Optical Sectioning to Improve the Performance of Cell Based Assays View Poster | ||
| Zhang, Wentao | ||
| CYP450 Inhibition Profiling Using High-Throughput RapidFire Mass Spectrometry Assays View Abstract | ||
| Zhang, Yaqin | ||
| Determination of Lipid Droplet Accumulation in Oleic Acid Treated Cells Using The Acumen eX3 View Abstract | ||
| Zhu, Mingde | ||
| Rapid Screening of 250 Supernatants Using Multiplexed SPR Technology & Real-Time Double Referencing View Abstract | ||
| Zhu, Ping | ||
| High-Throughput Screening for c-Jun N-terminal Kinase Inhibitors Using AlphaScreen in a 1536-well Format View Abstract | ||
| Zuzel, Timothy | ||
| Speeding the Compound Processing along the Research Super Highway View Abstract |
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SAGE publishes the Journal of Biomolecular Screening on behalf of the Society of Biomolecular Sciences Visit the journal online at jbsonline.sagepub.com |