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| P01 ADMET and Toxicology |
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| A Rapid Assay for p450 Inhibition/Induction Utilizing Ultra Performance Liquid Chromatography & Tandem Quadrupole Mass SpectrometryView Abstract |
| An AlphaLISA® Workstation – A Complete Solution for Immunoassay Simplification, Improved Performance, Maximized Throughput, Increased Sensitivity, & Assay Cost ReductionView Abstract View Poster |
| An Automated LC/MS/MS Protocol To Enhance Throughput of Physico-Chemical Property Profiling In Drug DiscoveryView Abstract |
| Application of Cellular Systems Biology to Cytotoxicity ProfilingView Abstract |
| CellCiphr – Cellular Systems Biology Assay for Hepatotoxicity Using Human HepG2 CellsView Abstract |
| CYP450 Inhibition Profiling Using High-Throughput RapidFire Mass Spectrometry AssaysView Abstract |
| Distribution of Cytochrome P450 Activity Across Known Drugs & Diverse Compound CollectionsView Abstract |
| Hepatocyte Culture Performance is Improved Over Current Methods When Cells are Grown On A Synthetic ECM-Mimetic Surface TopographyView Abstract |
| Identification of Cytochrome P450 Mechanism-Based Inhibitors Using In vitro High-Throughput AssayView Abstract |
| In vitroToxicity Screening by Transcription Factor Activity ProfilingView Abstract |
| Overt Toxicity Screening Assay Using Live Z-TagSM ZebrafishView Abstract View Poster |
| Predictive Cytotoxicity Measurements by Monitoring Heat Shock Proteins & the Cell Cycle in High-content Screening Cell-Based AssaysView Abstract View Poster |
| Stratgies to Reduce the Number of True Genotoxins Proceeding to Animal TestingView Abstract |
| The Use of Multi-Parametric High-Content Screening Assays to Monitor Cytotoxicity & Different Programmed Cell Death Pathways.View Abstract View Poster |
| The Use of Quantitative, Cell-based, High-Content Screening Assays to Detect In vitro Genotoxicity & the Effect on Cell Cycle CheckpointsView Abstract View Poster |
| Validation of Automated High-Throughput Plasma Protein Binding AssaysView Abstract |
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| P02 Advances in Assay Technology |
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| A Functional Assay for Gq-coupled GPCRs by Measuring Inositol Monophospate-1 in 1536-well Plate formatView Abstract |
| A General Method for Discovering Inhibitors of Protein-DNA Interactions Using Photonic Crystal BiosensorsView Abstract |
| A Genome-wide siRNA Screen for Identifying Novel Genes Involved in Maintaining Genomic StabilityView Abstract |
| A High-Throughput Permeability Screening Methodology Utilizing a Novel Artificial PAMPA Membrane & LC/MS/MS DetectionView Abstract |
| A New Aquesous Solubility Screen High-Throughput SonicationView Abstract View Poster |
| A Novel Fluorimetric Assay for Detection of TACE (Ą-secretase) Activity Using a Long Wavelength FRET Peptide SubstrateView Abstract |
| A Novel Incubation Procedure to Reduce Edge-Effect in High-Throughput Cell-Based AssaysView Abstract |
| A Novel Non-Fluorescent Quencher Dye Quenching a Broad Range of Fluorophores & Its Implementation in Protease Activity AssaysView Abstract |
| A Sensitive & Simple Homogeneous QRET Technology for Biomolecular ScreeningView Abstract |
| A Surface Plasmon Resonance Based Assay for the Detection & Characterization of Promiscuous InhibitorsView Abstract |
| An Assessment of Multiple Fluorescence Calcium Indicator Dyes in Three Diverse Recombinant Systems By Measurement in A Flipr Cell-Based Calcium Flux AssayView Abstract |
| Antibody-free Lck Kinase Fluorescence Lifetime AssayView Abstract View Poster |
| Application of EpicÒ System in Cell-based AssaysView Abstract |
| Application of plex-in-plex Branched DNA Assay in Quantitating mRNA in Early Drug DiscoveryView Abstract |
| Applying The Labcyte MicroClime Lid In Biological Assays To Improve Data Quality & Quantity.View Abstract |
| Assessment of the Immune Response Using High-content Screening Cell-based Imaging & Antibody ArraysView Abstract |
| Automatic Recptor Trafficking Assay Analysis using Machine LearningView Abstract |
| Automation & Miniaturization of Immunoassays for Drug Discovery AlphaLISA®, a Sensitive No-Wash AssayView Abstract View Poster |
| Automation of Pre-coated PAMPA Plates Improves Predictability, Reproducibility, & EfficiencyView Abstract |
| Cell-Permeable Fluorogenic Oligonucleotides Single Cell RNA Profiling, Antisense & siRNA Delivery, & Live Cell ImagingView Abstract View Poster |
| Cellular Protein Dynamics Studied With Covalently Labeling Protein TagsView Abstract |
| Comparison of a Cellular ELISA & AlphaScreen SureFire™ for Evaluation of Ligand Stimulated ERK Phosphorylation in Human Umbilical Vein Endothelial CellsView Abstract |
| Comparison of An Alphalisa Assay vs. ECL & ELISA Assays to Measure Abeta40 & Abeta42 Levels for HTS & Lead OptimizationView Abstract |
| Cyclic Olefin Polymer is a Superior Material For High-Density Multiwell Microtiter Plate ConstructionView Abstract |
| Detection of Caspase-3/7 Activity in Human Serum & Plasma as a Potential Biomarker of Apoptotic Cell Death Using the Promega Caspase-Glo® 3/7 AssayView Abstract |
| Detection of Ligand-Dependent Interaction of Nuclear Receptors with their Cofactor Using the Corning® Epic® SystemView Abstract |
| Development & Validation of a Protein-Protein Interaction HTS Assay Based on AlphaLisa™ TechnologyView Abstract |
| Development of 8 New No-Wash Immunoassay Kits for the Detection of VEGF, Amyloid Beta1-40, Amyloid Beta1-42, Insulin, Human IgG, EPO, HIV p24 & TNFalpha Using PerkinElmer AlphaLISAView Abstract View Poster |
| Development of a Non Binding Surface for Biochemical Assays & High-Throughput ScreeningView Abstract View Poster |
| Development of a Plasma Based Assay for Endothelial LipaseView Abstract |
| Development of Customized Immunoassays using AlphaLISA®View Abstract View Poster |
| Division Arrested Cells Simplifying Assay Design & Increasing FlexibilityView Abstract View Poster |
| Drug-Drug Interactions of Human Cytochrome P450s by a New Electrochemical ArrayView Abstract |
| Dynamic Protein Affinity Chromatography SPE-LC-MS Finding New Receptor Ligands in Complex MixturesView Abstract |
| Evaluation of AequoZen™ Frozen Cells Starter Kit using the Aequorin Option for the FLIPR TETRA® SystemView Abstract |
| ExpressLC – A Platform For Fast, Reliable Separation-Based Assays Using Microflow LC Separations & Nanoliter Volume DetectionView Abstract |
| FMAT Based Assay to Detect Antibodies Against Cell Surface ReceptorsView Abstract |
| GDP Detection Using the Transcreener TechnologyView Abstract |
| GPCR Screening and Profiling Using Arrestin Reveals Unique Pharmacology for Compounds on Known Receptors and Provides a Platform For Oprhan GPCRs in Discovery and Repositioning ApplicationsView Abstract |
| HIF-Prolyl Hydroxylase; Preparation of Multiple Reagents to Develop TR-FRET Assay for HTSView Abstract |
| High-Density STEP Array Plates A Novel Platform for Multiplexed GPCR ScreeningView Abstract |
| High-Throughput Assays for de novo DNA Synthesis using Click Chemistry Detection TechnologyView Abstract |
| High-Throughput Cell Migration Assay with the IsoCyte™ Laser Scanning PlatformView Abstract View Poster |
| HTS Flow Cytometry of Multiplexed Targets HTS Flow CytometryView Abstract |
| Immobilized Bead Assay System For Multiple Analyte DetectionView Abstract |
| Improvements in Data Quality & Assay Performance Using Aequorin for Calcium Based Screening.View Abstract |
| Introducing the CellKey™384 System, A Label-Free High-Throughput Cell-Based Assay for Functional Screening of Cellular ReceptorsView Abstract |
| Label Free Holographic Biosensors for Drug DiscoveryView Abstract |
| Label-Free Antibody Screening Sandwich Assay Using the Corning Epic® SystemView Abstract |
| Label-Free Determination of Kinetic Constants for Small Molecule Binding to Proteins Using FortéBio’s Octet RED Multi-Channel SystemView Abstract |
| Label-Free Optical Biosensor for Probing GPCR Ligand-Directed Functional SelectivityView Abstract |
| Label-Free Optical Biosensor for Probing Receptor Biology Theory, Modeling & ApplicationsView Abstract |
| LipoSignal A Homogeneous, Cell-Free Assay for Screening for Modulators of GPCR ActivationView Abstract |
| Maintaining 1536 Well Assay-Ready Microplate Reagent Integrity Using An Automatable Microplate Lid That Provides An Environmental Barrier SealView Abstract |
| Microchannel Assays Using Primary Tumor Cells, Co-culture & 3-dimensional Extracellular MatricesView Abstract |
| Multiplexing HCV Replicon Luciferase Assay With Cell-Titer Blue Toxicity Assay In HTS FormatView Abstract |
| nanoCF™ Assay System A Novel Tool for Mechanistic StudiesView Abstract |
nanoCF™ Assay system A Novel Tool for Mechanistic Studies
Part Two Compound Profiling & Mechanism of ActionView Abstract |
| New SA-PE Conjugates Improve Critical Assay Parameters in Sandwich Immunoassays Performed Using Luminex® xMAP® TechnologyView Abstract View Poster |
| New SA-PE Conjugates Reduce Capture-Antibody-Specific Background in Sandwich Immunoassays Performed Using Luminex® xMAP® TechnologyView Abstract View Poster |
| Novel Ratiometric Phospholipase A2 Specific Enzyme Substrate with a Fluorescence Donor & Acceptor PairView Abstract |
| Old Assays, New Instrument The Omega - High Speed, UV/Vis Spectrometer in a Microplate ReaderView Abstract |
| Optimizing Nucleic Acid Detection by Altering Detection ChemistryView Abstract View Poster |
| PhotoScreen™ luminescent Calcium Assays Applications on LumiLux® & FLIPRTETRA®View Abstract |
| Profiling for GPCR activation using DiscoveRx PathHunter B-Arrestin TechnologyView Abstract |
| Profiling the Activity of Proteasome Inhibitors Using Promega’s Proteasome-Glo™ Cell-Based AssayView Abstract |
| QT Prolongation Assay Using Beating Cardiomyocyte Derived From Monkey ES CellView Abstract |
| Quest Rhod-4™ Calcium Indicator, a New Red Fluorescent for Screening GPCR & Calcium Channel TargetsView Abstract |
| Receptor Selection & Amplification Technology A Unique, Powerful Screening Platform for Drug DiscoveryView Abstract |
| Ru TR-FRET Assays Evaluation of Two Acceptor Dyes & Comparison with Eu TR-FRET AssaysView Abstract |
| Selective Detection of Pyrophosphate Using a Fluorogenic Pyrophosphate SensorView Abstract |
| Stem Cell-Derived Neurons In CNS Drug DiscoveryView Abstract |
| Targeting & manipulating the STAT, M1-NFAT, & NFêB signaling pathways in quantitative high-throughput screening (qHTS) using a laser-scanning fluorescence microplate cytometerView Abstract |
| Template-Directed Self-Assembly Imparts Biological Relevance to Standard In vitro AssaysView Abstract |
| The CellKey™384 System Enables High-Throughput Screening with a Label-free Cell-Based Assay Platform.View Abstract |
| Utilizing Techniques in Developing & Optimizing Assay Paradigms to Increase Throughput in Screening Small Libraries & Special Compound CollectionsView Abstract |
| Validation of a Functional Screening Assay for Glycine Transporter 1 Inhibitors Using Cryopreserved CellsView Abstract |
| Watchmaker® - Compound Generation by Combinatorial Genetics & Screening in YeastView Abstract View Poster |
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| P03 Automation and Detection Platforms |
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| A Story in Method Transfer Troubleshooting Accuracy Matters When Transferring Quantitative, Manually-pipetted Assays to AutomationView Abstract |
| Advances in Automated Transporter Screening Parallelization Approach leads to Eight-Fold Increase in ThroughputView Abstract View Poster |
| Advances in Genomic Screening Through High-Throughput Viral ProductionView Abstract View Poster |
| Advances in High-Throughput Screening with the New LumiLux® CS Cellular luminescence Platform.View Abstract View Poster |
| An Automated Method for the Expansion & Neural Differentiation of Embryonic Stem CellsView Abstract View Poster |
| An Integrated Solution for Efficient Enzyme Panel ScreeningView Abstract |
| Automated High-Throughput Drug Discovery Using Surface Plasmon ResonanceView Abstract |
| Automatic Transfluor Assay Analysis using Machine LearningView Abstract |
| Development of the Octet RED System for Label-Free, Multi-channel Kinetic Analysis of Biomolecular InteractionsView Abstract View Poster |
| Duplex HTS Assay Measured Simultaneously With Nano-TRF & fluorescence Lifetime MethodView Abstract View Poster |
| Evaluation of the New EnVision Monochromator OptionView Abstract View Poster |
| Hamamatsu Photonic FDSS7000 The New uHTS System with Multi-Dispense & Multi-Detection mode.View Abstract |
| High-Throughput Automation of Cisbio’s IP-One HTRF® Assay using the BioRAPTR FRD Microfluidic Workstation & PARADIGM™ Detection PlatformView Abstract |
| High-Throughput Secondary Screening—1400 Dose-Response Curves per HourView Abstract |
| Increasing Efficiency & Maintaining Quality Running HTS on a 24/7 Schedule.View Abstract |
| Integration of a Labcyte Echo 550 Liquid Handler® with a Velocity 11 Element System™View Abstract |
| KingFisher® Flex – Flexible Automated Nucleic Acid, Protein & Cell PurificationView Abstract |
| Label-Free Characterization of Proteins Using Acoustic Droplet Ejection Deposition & Advanced X-Ray Technology MeasurementView Abstract View Poster |
| Optimizing Performance of the Transcreener™ ADP Assay for Commonly Used Multiwell ReadersView Abstract |
| Performing Cytotoxicity Assays with Sleeping Cells & Thermo Scientific Microplate ReadersView Abstract |
| Robust Kinetic Characterization of Moving Objects for Subcellular Time-lapse AssaysView Abstract |
| Screening & Development of Antibodies For Use in High-content Immunofluorescent Microscopy.View Abstract |
| Slide-based Miniaturized Microtiter Plate for ELISA & Cell-based AssaysView Abstract View Poster |
| The Synergy Family of Readers, A Lower Cost High Performance Alternative for Running AlphaScreen AssaysView Abstract View Poster |
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| P04 Biopharmaceuticals |
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| Rapid Selective In Situ Screening Of Hybridomas in Semisolid MediumView Abstract View Poster |
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| P05 Cells and Proteins in Drug Discovery |
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| A Multiplex Approach to Characterization of RTK & ERK Pathway SignalingView Abstract |
| A New Approach to Cell-Based Assays Mouse Embryonic Neural Stem CellsView Abstract |
| Automation of AlphaLISA Insulin & VEGF Immunoassays on JANUS Liquid Handling WorkstationView Abstract View Poster |
| Bioactive Coatings For Stem Cell Homing & Its Applications In Heart Valve Tissue EngineeringView Abstract |
| Cell Factory. Production of cryopreserved cells as reagents for screening assays.View Abstract |
| Development of Label Free Cellular Assays Using Primary Neuronal CellsView Abstract |
| Dimerization of BZIP Proteins in Living Cells Assayed by Fluorescence Imaging TechnologyView Abstract |
| Frozen Cells in Assay Plates for Instant Use in Cell-Based ScreeningView Abstract View Poster |
| Frozen Human Primary Cells for High-Throughput ScreeningView Abstract View Poster |
| One Stop Total Cell-Based Assay Solution with Invitrogen From Assay Validation to High-Throughput Screening in Few WeeksView Abstract |
| Production of Biologically Active Chemokines In E. ColiView Abstract View Poster |
| SPR Imaging, a Label-Free Method for the Analysis of MicroarraysView Abstract View Poster |
| The Application of Microcarrier Technology to The Provision of Receptor Membranes For High-Throughput ScreeningView Abstract |
| The Impact of Automated Clone Selection on the Cell Line Generation ProcessView Abstract |
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| P06 Compound Management |
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| A Modular Solution For Long Term Storage of Biological SamplesView Abstract |
| A new Paradigm in Sample Library Management & ReplicationView Abstract View Poster |
| Facing the Challenges of Supplying Assay Ready Plates Utilizing Special Library Sets to Obtain Novel Leads for the Hit to Lead Phase of Drug DiscoveryView Abstract |
| Maintaining the Integrity of the Wyeth Liquid SamplesView Abstract |
| Speeding the Compound Processing along the Research Super HighwayView Abstract |
| Storage Solutions New Technologies, New ApplicationsView Abstract |
| Successful Implementation of a Bio-Sample StoreView Abstract View Poster |
| The Great TransferView Abstract |
| Use of PocketTip for Both Compound Storage & ScreeningView Abstract |
| Validation of Low Volume 1536 “Assay Ready” Compound Plates for a Nuclear Hormone Receptor Screen.View Abstract View Poster |
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| P07 Data Processing and Analysis |
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| Beyond Biomolecular Screening A Multi-Parametric Procedure for Efficient Hit & Lead IdentificationView Abstract |
| Creative Ways to Increase our Screening Capacity in a Production Environment.View Abstract View Poster |
| Data Processing & Quality Assurance in a Kinetic Enzyme AssayView Abstract View Poster |
| HistopatholgicalSpectrum of Thymic Neoplasms Nine-years Research Survey at a SAL Hospital, Ahmedabad, IndiaView Abstract |
| M-Screen An Open-Source, Web-Based Application Package that Integrates Compound Management & High-Throughput Screening (HTS) Data AnalysisView Abstract |
| Mining Biological Screening Data in PubChemView Abstract |
| Spatio-Temporal Cell Segmentation & Tracking for Automated ScreeningView Abstract View Poster |
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| P08 High Content Screening |
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| A Heterogeneous Angiogenesis Assay Using Primary Cell Co-Culture In MicrochannelsView Abstract View Poster |
| A High-content Homogeneous Assay for P-Glycoprotein Inhibition using Microplate CytometryView Abstract |
| A New Fluorescent Mitochondrial Membrane Potential Sensor for Imaging & Fluorescence Plate Reader-Based ApplicationsView Abstract |
| Assessment of PI3-Kinase & AKT Signaling Using Quantitative Cell-Based Immunofluorescence High-content Screening AssaysView Abstract View Poster |
| Brightfield as a Label Free Adjunct to Fluorescence High-content Screening for Improved Assay Performance & Data QualityView Abstract View Poster |
| Cell Cycle Drug Profiling by BrdU Incorporation, Histone H3 Phosphorylation, Cytoskeletal Rearrangement, & Cell Morphology Changes by Multiplexed High-Content Screening AssaysView Abstract View Poster |
| Complete Automated Solution for HLA Antibody Detection Using Multiplex xMAP TechnologyView Abstract |
| Compound Selectivity & Specificity Profiling Using Functional Protein MicroarraysView Abstract |
| Determination of Lipid Droplet Accumulation in Oleic Acid Treated Cells Using The Acumen eX3View Abstract |
| Full Automation of Magnetic Bead-Based Luminex xMAP Cytokine Assays on the PerkinElmer JANUS® Automated Liquid Handling PlatformView Abstract View Poster |
| High-content Image Analysis Using a Laser Scanning Microplate CytometerView Abstract |
| High-content Screening Assays for Neurotoxicity ProfilingView Abstract |
| High-content Screening Enables High-Throughput ScreeningView Abstract |
| High-throughput DNA Damage Assay for Breast Cancer Related Protein Markers using the IsoCyte™ PlatformView Abstract |
| High-Throughput Fluorescence Lifetime Based Assays for Protein KinasesView Abstract |
| Imaging PML Nuclear Bodies Using a High-content Imaging PlatformView Abstract View Poster |
| Intracellular Nitric Oxide (NO) Generation Rates Correlate With Different No Synthases’ Expression Levels, At The Resolution of Individual Living CellsView Abstract |
| Label-free Analysis of Tissue Sections & Cells Using Laser Scanning Reflectance ImagingView Abstract |
| Multiplexed High-content Screening Assays for Cell Cycle Analysis & Cytotoxicity ProfilingView Abstract |
| Navigating the High-content Imaging ProcessView Abstract |
| PamChip Peptide Micro Array Technology Applications in Kinase & Nuclear Receptor ResearchView Abstract |
| Processware - An Order of Magnitude Improvement in LIMS TechnologyView Abstract View Poster |
| Quantitative Analysis of Angiogenesis & Cytoskeletal Formation with IN Cell InvestigatorView Abstract View Poster |
| Quantitative High-Content Analysis of Intracellular Oxidative Stress & DNA DamageView Abstract View Poster |
| Rapid Screening of 250 Supernatants Using Multiplexed SPR Technology & Real-Time Double ReferencingView Abstract |
| Screening for Estrogen Receptor á (ERá) Ligands Using Nuclear Translocation AnalysisView Abstract |
| Sub-Cellular Resolution Genome Wide RNA Interference Analysis Within A DayView Abstract View Poster |
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| P09 Liquid Handling and Microfluidics |
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| Automated Low Volume Cell Dispensing & Analysis Using the BioRAPTR FRD Microfluidic Workstation & PARADIGM™ Detection Platform for cAMP & Ion Channel AssaysView Abstract |
| Best Practices for Assessing Nanoliter Transfer Performance for Acoustic Droplet Ejection Liquid H&lersView Abstract |
| Differential Cell Adhesion Within An Isogenic Model Of Melanoma Progression Under Shear Flow Conditions Using Cellix’s Venafluxtm PlatformView Abstract |
| Evaluation of Nanoliter Transfer using Acoustic Droplet EjectionView Abstract |
| High-Throughput Kinase Selectivity Profiling for Drug Discovery ApplicationsView Abstract |
| Improving the efficiency of 384 “mini-tube” Technology Using Mosquito® nanolitre pipettingView Abstract |
| Improving the Efficiency Of 384 “mini-tube” Technology Using Mosquito® Nanolitre PipettingView Abstract |
| Liquid Delivery Errors – The Impact of Laboratory Conditions on Pipetting PerformanceView Abstract |
| Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution using mosquito ®View Abstract |
| Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution Using mosquito ®View Abstract |
| PCR Set Up in LightCycler® Carousels Using VERSA WorkstationsView Abstract View Poster |
| Real-time Reaction Monitoring & Enzyme Kinetics Measurements on the ExpressLC platformView Abstract |
| The Effects of Pipette Tip Material & Sterilization on the Retention of Aqueous LiquidsView Abstract |
| Toward Routine Assays in 200 nL VolumesView Abstract |
| Utilizing Nano25 Low Volume Dispenser for Hit OptimizationView Abstract |
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| P10 Structural Bio - Lib Design and Lead Opt |
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| Antimalarial Drug Discovery From Target Validation to Lead QualificationView Abstract |
| Atomic-level Structural & Kinetic Analysis of Integral Membrane Protein Binding InteractionsView Abstract |
| Structural Mapping Of Gpcr Interactions With Ligands, Drugs, & AntibodiesView Abstract |
| What Structural Features Explain why Some Fragments of the Molecule are Important While Others are not?View Abstract |
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| P11 Target Biology and Screening GPCRs |
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| A New Robust No-Wash FLIPR Calcium Assay Kit for Screening GPCR & Calcium Channel TargetsView Abstract View Poster |
| A New Technology for G-protein Coupled Receptors Analysis Conformational Specific Antibodies.View Abstract View Poster |
| Adrenergic Receptor Family Membrane Preparation Array With Millipore's MultiScreenHTS Glass Fiber Filter PlatesView Abstract |
| Aequorin Plasmids A Novel Tool for Generating Cell Lines for Luminescence AssaysView Abstract View Poster |
| An Aequorin Luminescence-Based Assay for Monitoring GPCR Function in Cryopreserved CHO Cells Transiently Expressing Either a Receptor-of-Interest or Apo-aequorin-3View Abstract |
| An RGS protein HTS assay Strategy using the Transcreener™ GDP AssayView Abstract |
| Biosensor Screening & Analysis of GPCR Interaction KineticsView Abstract |
| Building the Predictor™ Fluorescence Polarization Assay for High-Throughput Screening of hERG Channel AffinityView Abstract |
| Comparison of Aequorin to Flourescent Dye for GPCR Calcium Flux Using Cells Transfected With The Human Free Fatty Acid (FFA1) Receptor (GPR40).View Abstract View Poster |
| Comparison of Photina® Luminescent Calcium Mobilization Assays on both the FlexStation 3® & the FLIPRTETRA® SystemsView Abstract |
| Determination of a Galpha/i-coupled Receptor Activity Using CISBIO’s Membrane-based cAMP HiRange® kitView Abstract |
| Development of a Panel of cAMP Hunter™ Cell Lines for Analysis of Naturally Coupled GPCRs Using the DiscoveRx HitHunter™ cAMP Detection Kits.View Abstract |
| Direct Fluorescent Labelling Approaches for G-protein Coupled Receptors & Imaging Using the Opera™ High-Content Screening PlatformView Abstract View Poster |
| Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor 8 (mGluR8) using GIRK-mediated Thallium Flux Modulation in High-Throughput ScreeningView Abstract View Poster |
| Dual Purpose Cell Lines for Analysis of GPCR/Arrestin Interaction Using PathHunter & Natural Gq-coupling Using the Improved Calcium No-Wash PLUS Kit.View Abstract |
| Endogenous Receptor Characterization in Normal Lung Cells by Cellular Dielectric Spectroscopy & RNA InterferenceView Abstract |
| Establishment of Functional Assays that Discriminate Between Neutral Antagonists & Inverse agonistsView Abstract |
| HitHunter™ cAMP Assays Versatile Assays Validated for Multiple ApplicationsView Abstract |
| Identification of GPR23 Agonists, Antagonists & Inverse Agonists by High-throughput ScreeningView Abstract |
| Improvements in GPCR & calcium channel screening using Second Generation BD Calcium Assay KitsView Abstract |
| Introduction of a new TR-FRET Terbium Cryptate IP-One Tb, a new generation HTRF® kit applied to GPCR Screening & InvestigationView Abstract |
| Label-Free Cell-Based Screening for GPCR Agonists & Antagonists using the Corning® Epic® SystemView Abstract |
| Label-Free Optical Biosensor for Probing the Roles of Adenylate Cyclases in Signaling Integration of G Protein-Coupled ReceptorsView Abstract |
| Leveraging Early Liability & Drug Safety Assessment by Integration of Innovative Screening Automation, High-Throughput Reagent Generation & Novel Bioassay TechnologyView Abstract |
| Miniaturization of the HitHunter™ cAMP XS+ Assay for Gs/Gi Screening in 1536 Well Plate Format.View Abstract |
| New Aequorin Parental Cell Lines for Screening of GPCRsView Abstract View Poster |
| Unveiling Drug Selectivity Via Functional Profiling & Multi-Prong Approach To Hit Validation Using ChemiScreen™ GPCR Cell LinesView Abstract View Poster |
| Utilization of PathHunter Arrestin Cell Lines for Detection of Arrestin Biased Ligands & Compound Pharmacology Distinct from Second Messengers.View Abstract |
| Validation of Different Aequorin Mutants for GPCR Screening Using the FLIPRTETRA® System with Aequorin OptionView Abstract |
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| P12 Target Biology and Screening Ion Channels |
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| An Automated Microfluidic Dose-Response System for Ion ChannelsView Abstract |
| An Ion Channel FLIPR HTS Using the New Fluo-8 Calcium DyeView Abstract View Poster |
| Optimization of High-Throughput Ion Channel Screens Using Single Cell & Population AnalysesView Abstract |
| Primary Human Cells & BacMam Target Delivery in a Novel, High-Throughput Assay of hERG FunctionView Abstract View Poster |
| Taming the EDG Receptor Family with the Tango™ TechnologyView Abstract |
| Using Surface Plasmon Resonance & the Acetylcholine Binding Protein to Screen for Ligands for the Nicotinic Acetylcholine ReceptorView Abstract |
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| P13 Target Biology and Screening Kinases |
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| A Kinase Focused RNAi Screen Identifies Novel Mediators of ApoptosisView Abstract |
| A Quantitative Analysis of Kinase Inhibitor SelectivityView Abstract |
| ADPHunter™ Plus Extended Application for Detection of GDP & UDP ProductionView Abstract |
| Advances in HTS Methods for Interrogation of the PI3K/Akt/mTOR PathwayView Abstract View Poster |
| An Optimized ADP Accumulation Assay For PI3 Kinase Primary Screening & Inhibitor CharacterizationView Abstract |
| Analysis of Kinase Inhibitors using a Large Array of Signaling Antibodies & High-content Screening.View Abstract View Poster |
| Beyond Kinases Interrogating the PurinomeView Abstract |
| Biochemical Assays for Selectivity Profiling Across the Entire PI3 Kinase FamilyView Abstract |
| Chemical-Kinomic Approach to Analyze the Selectivity of Kinase InhibitorsView Abstract |
| Development of a High-Throughput LanthaScreen Assay for DNA-dependent Protein KinaseView Abstract |
| Development of an Automated AlphaScreen for Detection of MEK Phosphorylation in a Transiently Transfected Cellular ModelView Abstract |
| Development of COT, mTOR & NEK6 Kinase Assays Using the LANCE® Ultra ULight™-p70 S6K (Thr389) PeptideView Abstract View Poster |
| Further Characterization of BIRB0796 using Multiple Target Class ProfilingView Abstract |
| High-Throughput Screening for c-Jun N-terminal Kinase Inhibitors Using AlphaScreen in a 1536-well FormatView Abstract |
| Homogeneous Time-Resolved Fluorescence-Based Assay for Phosphorylated Peptides Using a Generic BinderView Abstract |
| HTRF as a Reliable Platform for Large Scale Kinase ProfilingView Abstract |
| HTRF® Transcreener™ ADP Assay The New Solution for ADP DetectionView Abstract |
| Interrogation of the National Institutes of Health Small Molecule Repository for Protein Kinase D InhibitorsView Abstract |
| Kinase Assay Development Using Acoustic Droplet Ejection TechnologyView Abstract |
| Kinase Inhibitor Profiling & Compound Characterization on a Microfluidic Mobility-Shift PlatformView Abstract |
| Kinase Selectivity Profiling on EZ Reader™ – 144 Kinases Against 12 Compounds in a Day.View Abstract |
| Luminescent Assay Optimization, Kinase Profiling, & uHTS ApplicationView Abstract View Poster |
| PathHunter™ Protein Interaction Assays for Analysis of Receptor Kinase Dimerization in Whole Cells.View Abstract |
| Rapid Improvement of Protein Stability by Thermal ProfilingView Abstract |
| Screening of a Kinase Enzyme Utilizing IMAP Assay & EnVision Multi-format Plate Reader Technologies.View Abstract View Poster |
| Serine/Threonine Kinase Profiling using the LANCE® Ultra KinaSelect™ Ser/Thr KitView Abstract View Poster |
| Steady State Characterization of Death Associated Protein Kinase 1 Using Microfluidic TechnologyView Abstract View Poster |
| Three Kinase Screening Assays Using a Generic ADP Detection MethodView Abstract View Poster |
| Tools & Processes to Drive Data Quality & Throughput for Biochemical & Cellular Compound ProfilingView Abstract View Poster |
| Use of IMAP TR-FRET Detection Mode for the IMAP AGC & CAMK Group Substrate FinderView Abstract |
| Use of IMAP TR-FRET Detection Mode for the IMAP Tyrosine Kinase Group Substrate FinderView Abstract |
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| P14 Target Biology and Screening Other Targets |
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| A Bioactivity Screen to Identify Novel Toll-Like Receptor Peptide Agonists for Use as Vaccine AdjuvantsView Abstract |
| A High-Throughput Screening Assay to Identify Novel Compounds that Differentially Inhibit Cell Proliferation of ARMS & ERMSView Abstract |
| A Quantitative High-Throughput Screen for LMNA Splicing ModulatorsView Abstract |
| Addressing the Tractability of Difficult Viral Targets Approaches Toward the Discovery of Antivirals for Lethal RNA Viruses that Require BiocontainmentView Abstract |
| Antagonizing mPGES-1 Developing a High-Throughput Screening AssayView Abstract |
| Antituberculosis High-Throughput Dug Screening at Southern Research InstituteView Abstract View Poster |
| Application of the Calcium-Sensitive Reporter Photina® to Generate HTS Assays for Na/Ca2+ Exchangers.View Abstract |
| Application of the Transcreener™ AMP/GMP Assay for Interrogating Ubiquitinylation CascadesView Abstract |
| Complementary Cell-Based Screens Identify Specific Inhibitors of the Unfolded Protein Response Apoptotic Sub-Pathway and Reduce False Positive HitsView Abstract |
| Development of a Novel High-Throughput Screening Assay to Identify both Agonist/potentiator & Antagonist of Pregnane X Receptor (PXR)View Abstract |
| Drug Discovery for Muscular DystrophiesView Abstract View Poster |
| From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction through the HIV-1 Integrase / human LEDGF-Case Study.View Abstract |
| From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction Through the HIV-1 Integrase / LEDGF-Case StudyView Abstract |
| High-throughput Screening Identifies Novel Inhibitors for Bacillus Anthracis O-succinylbenzoyl-CoA SynthetaseView Abstract |
| High-Throughput Screening of HAUSP Inhibitors Using the TR-FRET Based DUB SubstrateView Abstract |
| HTRF® Deacetylation Assay A new solution for HDAC/SIRT ScreeningView Abstract |
| Human Anti-Angiogenesis High-Throughput Screening Assay in 384-Well FormatView Abstract View Poster |
| Identification of MMP-12 Inhibitors by a Biosensor-Based Screening of a Fragment LibraryView Abstract View Poster |
| Identification of Novel Therapeutics for Treatment of Huntington’s Disease – a Phenotypic Screening CascadeView Abstract View Poster |
| Mechanistic evaluation of natural product inhibitors of HIV-1 RNaseView Abstract |
| MRC Technology’s Drug Discovery Group; a Mechanism for De-risking Novel Targets Emerging from Academia.View Abstract |
| Multiplexing Fluorescent & Chemiluminescent Live Cell Reporters to Dissect NFkB Signal Transduction RequirementsView Abstract |
| PathHunter™ NHR Protein Interaction Cell Lines Study Nuclear Hormone Receptors Without Using Reporter Gene AssaysView Abstract |
| Permeability Studies Of Coumarins With New Modified Caco-2 Cell ModelView Abstract |
| Phosphodiesterases A Novel Microfluidic Mobility-Shift Assay for Inhibitor Screening & ProfilingView Abstract |
| Purification & Enzymatic Characterization of Recombinant ADAMTS-5 in Aggrecan based MSD AssayView Abstract |
| Screening against Proteases Comparison of QFRET Substrates & Miniaturization of a Plasma Protein Shift AssayView Abstract View Poster |
| Screening for Modulators of Notch Signaling using a Luciferase Complementation-Based ReporterView Abstract |
| Screening of Antimicrobial Compounds in Fungal Extracts against Gram-positive & Gram-negative BacteriaView Abstract |
| Screening the NIH’s Compound Library to Identify Inhibitor Probes of Human Immunodeficiency Virus Reverse Transcriptase-associated Ribonuclease H Activity.View Abstract |
| Strategies for Improving the Impact of High-Throughput Screening CampaignsView Abstract View Poster |
| The Southern Research Molecular Libraries Screening CenterView Abstract |
| The use of Isothrmal Titration Calorimetry to Determine Enzyme Kinetic Constants for PP1-gamma PhosphataseView Abstract |
The Use of QuickZyme™ for the Identification of Novel Inhibitors of Anthrax Lethal Factor
We Report On Our Efforts Using the QuickZyme™ Technology Platform for the Identification of Novel Inhibitors of Anthrax Lethal Factor (ALF)View Abstract View Poster |
| Use of a High-Throughput Phosphodiesterase Profiling Platform to Study Inhibitors SelectivityView Abstract |
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| P15 Target Identification and Validation |
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| A 1536-well Based AlphaScreen Assay for Tdp1 Inhibitor IdentificationView Abstract |
| AKAP18 - A Potential Drug Target in Heart Failure Patients?View Abstract |
| Drug Target Discovery In Huntington Disease Cell Death Modifiers Identified With Adenoviral Shrna TechnologyView Abstract |
| Electroporation-based System for Genome Wide RNAi ScreeningView Abstract |
| Functional Characterization of Positive Allosteric Modulators of a7 Nicotinic Acetylcholine Receptors in IMR-32 Neuroblastoma CellsView Abstract View Poster |
| Rapid Generation of Epitope-Specific Recombinant Antibodies Using in vitro Selection TechnologyView Abstract View Poster |
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| Application of HCS Technology to Detect Receptor Internalization to Identify Selective CB2 Receptor AgonistsView Poster |
| Simultaneous on-line bioaffinity screening and identity characterization of metabolic mixtures for fast and comprehensive metabolic profilingView Poster |
| Using Optical Sectioning to Improve the Performance of Cell Based AssaysView Poster |
