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SBS 14th Annual Conference & Exhibition

April 6 - 10, 2008 . America's Center . St. Louis, MO

 
 
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A 1536-well Based AlphaScreen Assay for Tdp1 Inhibitor Identification
Wendy Lea View Abstract 
A Bioactivity Screen to Identify Novel Toll-Like Receptor Peptide Agonists for Use as Vaccine Adjuvants
Diane Stark View Abstract 
A Functional Assay for Gq-coupled GPCRs by Measuring Inositol Monophospate-1 in 1536-well Plate format
Ke Liu View Abstract 
A General Method for Discovering Inhibitors of Protein-DNA Interactions Using Photonic Crystal Biosensors
Leo Chan View Abstract 
A Genome-wide siRNA Screen for Identifying Novel Genes Involved in Maintaining Genomic Stability
Deena Soni View Abstract 
A Heterogeneous Angiogenesis Assay Using Primary Cell Co-Culture In Microchannels
Allyson Skoien View Abstract View Poster
A High-content Homogeneous Assay for P-Glycoprotein Inhibition using Microplate Cytometry
Jas Sanghera View Abstract 
A High-Throughput Permeability Screening Methodology Utilizing a Novel Artificial PAMPA Membrane & LC/MS/MS Detection
Grace Poon View Abstract 
A High-Throughput Screening Assay to Identify Novel Compounds that Differentially Inhibit Cell Proliferation of ARMS & ERMS
Fu-Yue Zeng View Abstract 
A Kinase Focused RNAi Screen Identifies Novel Mediators of Apoptosis
Leonid Tarassishin View Abstract 
A Modular Solution For Long Term Storage of Biological Samples
Ben Schenker View Abstract 
A Multiplex Approach to Characterization of RTK & ERK Pathway Signaling
Kathy Harings View Abstract 
A New Approach to Cell-Based Assays  Mouse Embryonic Neural Stem Cells
Stacey Szymanski View Abstract 
A New Aquesous Solubility Screen High-Throughput Sonication
Kevin Oldenburg View Abstract View Poster
A New Fluorescent Mitochondrial Membrane Potential Sensor for Imaging & Fluorescence Plate Reader-Based Applications
Jianming Lu View Abstract 
A new Paradigm in Sample Library Management & Replication
Julio Maher View Abstract View Poster
A New Robust No-Wash FLIPR Calcium Assay Kit for Screening GPCR & Calcium Channel Targets
Zhenjun Diwu View Abstract View Poster
A New Technology for G-protein Coupled Receptors Analysis  Conformational Specific Antibodies.
Andrea Heimann View Abstract View Poster
A Novel Fluorimetric Assay for Detection of TACE (fÑ-secretase) Activity Using a Long Wavelength FRET Peptide Substrate
Cecilia Po View Abstract 
A Novel Incubation Procedure to Reduce Edge-Effect in High-Throughput Cell-Based Assays
Yan Zhai View Abstract 
A Novel Non-Fluorescent Quencher Dye Quenching a Broad Range of Fluorophores & Its Implementation in Protease Activity Assays
Xinzhan Peng View Abstract 
A Quantitative Analysis of Kinase Inhibitor Selectivity
Mazen Karaman View Abstract 
A Quantitative High-Throughput Screen for LMNA Splicing Modulators
Cordelle Tanega View Abstract 
A Rapid Assay for p450 Inhibition/Induction Utilizing Ultra Performance Liquid Chromatography & Tandem Quadrupole Mass Spectrometry
Paul Rainville View Abstract 
A Sensitive & Simple Homogeneous QRET Technology for Biomolecular Screening
Harri Härmä View Abstract 
A Story in Method Transfer Troubleshooting  Accuracy Matters When Transferring Quantitative, Manually-pipetted Assays to Automation
Robert Pineau View Abstract 
A Surface Plasmon Resonance Based Assay for the Detection & Characterization of Promiscuous Inhibitors
Anthony Giannetti View Abstract 
Addressing the Tractability of Difficult Viral Targets Approaches Toward the Discovery of Antivirals for Lethal RNA Viruses that Require Biocontainment
Colleen Jonsson View Abstract 
ADPHunterT Plus  Extended Application for Detection of GDP & UDP Production
William Newsome, III View Abstract 
Adrenergic Receptor Family Membrane Preparation Array With Millipore's MultiScreenHTS Glass Fiber Filter Plates
Lucas Armstrong View Abstract 
Advances in Automated Transporter Screening  Parallelization Approach leads to Eight-Fold Increase in Throughput
Per Sörensen View Abstract View Poster
Advances in Genomic Screening Through  High-Throughput Viral Production
Loren Miraglia View Abstract View Poster
Advances in High-Throughput Screening with the New LumiLux® CS Cellular luminescence Platform.
Lee Brady View Abstract View Poster
Advances in HTS Methods for Interrogation of the PI3K/Akt/mTOR Pathway
Coby Carlson View Abstract View Poster
Aequorin Plasmids A Novel Tool for Generating Cell Lines for Luminescence Assays
Sandra Flores View Abstract View Poster
AKAP18 - A Potential Drug Target in Heart Failure Patients?
Birgitte Lygren View Abstract 
An Aequorin Luminescence-Based Assay for Monitoring GPCR Function in Cryopreserved CHO Cells Transiently Expressing Either a Receptor-of-Interest or Apo-aequorin-3
Beverly Holskin View Abstract 
An AlphaLISA® Workstation - A Complete Solution for Immunoassay Simplification, Improved Performance, Maximized Throughput, Increased Sensitivity, & Assay Cost Reduction
Ken Neumann View Abstract View Poster
An Assessment of Multiple Fluorescence Calcium Indicator Dyes in Three Diverse Recombinant Systems By Measurement in A Flipr Cell-Based Calcium Flux Assay
Yeung Wai View Abstract 
An Automated LC/MS/MS Protocol To Enhance Throughput of Physico-Chemical Property Profiling In Drug Discovery
Darcy Shave View Abstract 
An Automated Method for the Expansion & Neural Differentiation of Embryonic Stem Cells
Libby Kellard View Abstract View Poster
An Automated Microfluidic Dose-Response System for Ion Channels
Cristian Ionescu View Abstract 
An Integrated Solution for Efficient Enzyme Panel Screening
Jack Dawson View Abstract 
An Ion Channel FLIPR HTS Using the New Fluo-8 Calcium Dye
Qing-Fen Gan View Abstract View Poster
An Optimized ADP Accumulation Assay For PI3 Kinase Primary Screening & Inhibitor Characterization
Sailaja Kuchibhatla View Abstract 
An RGS protein HTS assay Strategy using the TranscreenerT GDP Assay
Rick Roncinske View Abstract 
Analysis of Kinase Inhibitors using a Large Array of Signaling Antibodies & High-content Screening.
Randy Wetzel View Abstract View Poster
Antagonizing mPGES-1  Developing a High-Throughput Screening Assay
Charles Lunn View Abstract 
Antibody-free Lck Kinase Fluorescence Lifetime Assay
Pierre Graves View Abstract View Poster
Antimalarial Drug Discovery From Target Validation to Lead Qualification
Didier LeRoy View Abstract 
Antituberculosis High-Throughput Dug Screening at Southern Research Institute
Lucile White View Abstract View Poster
Application of Cellular Systems Biology to Cytotoxicity Profiling
Lawrence Vernetti View Abstract 
Application of EpicÒ System in Cell-based Assays
Hong Xin View Abstract 
Application of HCS Technology to Detect Receptor Internalization to Identify Selective CB2 Receptor Agonists
Danli Towne View Poster
Application of plex-in-plex Branched DNA Assay in Quantitating mRNA in Early Drug Discovery
Pramod Pandey View Abstract 
Application of the Calcium-Sensitive Reporter Photina® to Generate HTS Assays for Na/Ca2+ Exchangers.
Lia Scarabottolo View Abstract 
Application of the TranscreenerT AMP/GMP Assay for Interrogating Ubiquitinylation Cascades
Robert Lowery View Abstract 
Applying The Labcyte MicroClime Lid In Biological Assays To Improve Data Quality & Quantity.
Adrian Freeman View Abstract 
Assessment of PI3-Kinase & AKT Signaling Using Quantitative Cell-Based Immunofluorescence High-content Screening Assays
Richik Ghosh View Abstract View Poster
Assessment of the Immune Response Using High-content Screening Cell-based Imaging & Antibody Arrays
Brian Webb View Abstract 
Atomic-level Structural & Kinetic Analysis of Integral Membrane Protein Binding Interactions
Benjamin Doranz View Abstract 
Automated High-Throughput Drug Discovery Using Surface Plasmon Resonance
Takayuki Yamada View Abstract 
Automated Low Volume Cell Dispensing & Analysis Using the BioRAPTR FRD Microfluidic Workstation & PARADIGMT Detection Platform for cAMP & Ion Channel Assays
Li Liu View Abstract 
Automatic Recptor Trafficking Assay Analysis using Machine Learning
James Lee View Abstract 
Automatic Transfluor Assay Analysis using Machine Learning
Samuel Alworth View Abstract 
Automation & Miniaturization of Immunoassays for Drug Discovery  AlphaLISA®, a Sensitive No-Wash Assay
Sophie Dahan View Abstract View Poster
Automation of AlphaLISA Insulin & VEGF Immunoassays on JANUS Liquid Handling Workstation
Dianne Brazzill View Abstract View Poster
Automation of Pre-coated PAMPA Plates Improves Predictability, Reproducibility, & Efficiency
Kevin Chen View Abstract 
Best Practices for Assessing Nanoliter Transfer Performance for Acoustic Droplet Ejection Liquid H&lers
Bruce Jamieson View Abstract 
Beyond Biomolecular Screening  A Multi-Parametric Procedure for Efficient Hit & Lead Identification
Laila Kabous View Abstract 
Beyond Kinases  Interrogating the Purinome
Bob Harrington View Abstract 
Bioactive Coatings For Stem Cell Homing & Its Applications In Heart Valve Tissue Engineering
Geofrey De Visscher View Abstract 
Biochemical Assays for Selectivity Profiling Across the Entire PI3 Kinase Family
Yi Gao View Abstract 
Biosensor Screening & Analysis of GPCR Interaction Kinetics
Sharon Willis View Abstract 
Brightfield as a Label Free Adjunct to Fluorescence High-content Screening for Improved Assay Performance & Data Quality
Kris Ver Donck View Abstract View Poster
Building the PredictorT Fluorescence Polarization Assay for High-Throughput Screening of hERG Channel Affinity
David Piper View Abstract 
Cell Cycle Drug Profiling by BrdU Incorporation, Histone H3 Phosphorylation, Cytoskeletal Rearrangement, & Cell Morphology Changes by Multiplexed High-Content Screening Assays
Michael Anhalt View Abstract View Poster
Cell Factory. Production of cryopreserved cells as reagents for screening assays.
Bob Kendall View Abstract 
Cell-Permeable Fluorogenic Oligonucleotides Single Cell RNA Profiling, Antisense & siRNA Delivery, & Live Cell Imaging
Akira Komoriya View Abstract View Poster
CellCiphr - Cellular Systems Biology Assay for Hepatotoxicity Using Human HepG2 Cells
Stella Redpath View Abstract 
Cellular Protein Dynamics Studied With Covalently Labeling Protein Tags
Andreas Brecht View Abstract 
Chemical-Kinomic Approach to Analyze the Selectivity of Kinase Inhibitors
Haiching Ma View Abstract 
Comparison of a Cellular ELISA & AlphaScreen SureFireT  for Evaluation of Ligand Stimulated ERK Phosphorylation in Human Umbilical Vein Endothelial Cells
Xiu-juan Yuan View Abstract 
Comparison of Aequorin to Flourescent Dye for GPCR Calcium Flux Using Cells Transfected With The Human Free Fatty Acid (FFA1) Receptor (GPR40).
Jack Kauffman View Abstract View Poster
Comparison of An Alphalisa Assay vs. ECL & ELISA Assays to Measure Abeta40 & Abeta42 Levels for HTS & Lead Optimization
Bethany Hughes View Abstract 
Comparison of Photina® Luminescent Calcium Mobilization Assays on both the FlexStation 3® & the FLIPRTETRA® Systems
Cerys Huggins View Abstract 
Complementary Cell-Based Screens Identify Specific Inhibitors of the Unfolded Protein Response Apoptotic Sub-Pathway and Reduce False Positive Hits
Martha Larsen View Abstract 
Complete Automated Solution for HLA Antibody Detection Using Multiplex xMAP Technology
David Bourdon View Abstract 
Compound Selectivity & Specificity Profiling Using Functional Protein Microarrays
Dawn Mattoon View Abstract 
Creative Ways to Increase our Screening Capacity in a Production Environment.
Rachel Russell View Abstract View Poster
Cyclic Olefin Polymer is a Superior Material For High-Density Multiwell Microtiter Plate Construction
Walter Niles View Abstract 
CYP450 Inhibition Profiling Using High-Throughput RapidFire Mass Spectrometry Assays
Wentao Zhang View Abstract 
Data Processing & Quality Assurance in a Kinetic Enzyme Assay
Melinda Sosa View Abstract View Poster
Detection of Caspase-3/7 Activity in Human Serum & Plasma as a Potential Biomarker of Apoptotic Cell Death Using the Promega Caspase-Glo® 3/7 Assay
Matthew Peach View Abstract 
Detection of Ligand-Dependent Interaction of Nuclear Receptors with their Cofactor Using the Corning® Epic® System
Jack Fang View Abstract 
Determination of  a Galpha/i-coupled Receptor Activity Using CISBIO's Membrane-based cAMP HiRange® kit
Jean-Luc Tardieu View Abstract 
Determination of Lipid Droplet Accumulation in Oleic Acid Treated Cells Using The Acumen eX3
Yaqin Zhang View Abstract 
Development & Validation of a Protein-Protein Interaction HTS Assay Based on AlphaLisaT Technology
Cleofe Zapatero View Abstract 
Development of 8 New No-Wash Immunoassay Kits for the Detection of VEGF, Amyloid  Beta1-40, Amyloid Beta1-42, Insulin, Human IgG, EPO, HIV p24 & TNFalpha Using PerkinElmer AlphaLISA
Stephane Parent View Abstract View Poster
Development of a High-Throughput LanthaScreen Assay for DNA-dependent Protein Kinase
Derek Poore View Abstract 
Development of a Non Binding Surface for Biochemical Assays & High-Throughput Screening
Rainer Heller View Abstract View Poster
Development of a Novel High-Throughput Screening Assay to Identify both Agonist/potentiator & Antagonist of Pregnane X Receptor (PXR)
Wenwei Lin View Abstract 
Development of a Panel of cAMP HunterT Cell Lines for Analysis of Naturally Coupled GPCRs Using the DiscoveRx HitHunterT cAMP Detection Kits.
Rocco Raduazo View Abstract 
Development of a Plasma Based Assay for Endothelial Lipase
Benjamin Schwartz View Abstract 
Development of an Automated AlphaScreen for Detection of MEK Phosphorylation in a Transiently Transfected Cellular Model
Brian Kraybill View Abstract 
Development of COT, mTOR & NEK6 Kinase Assays Using the LANCE® Ultra ULightT-p70 S6K (Thr389) Peptide
Jaime Padros View Abstract View Poster
Development of Customized Immunoassays using AlphaLISA®
Sara Howland View Abstract View Poster
Development of Label Free Cellular Assays Using Primary Neuronal Cells
Jason Brown View Abstract 
Development of the Octet RED System for Label-Free, Multi-channel Kinetic Analysis of Biomolecular Interactions
Krista Witte View Abstract View Poster
Differential Cell Adhesion Within An Isogenic Model Of Melanoma Progression Under Shear Flow Conditions Using Cellix's Venafluxtm Platform
Kate Fitzgerald View Abstract 
Dimerization of BZIP Proteins in Living Cells Assayed by Fluorescence Imaging Technology
Sarah Heyerdahl View Abstract 
Direct Fluorescent Labelling Approaches for G-protein Coupled Receptors & Imaging Using the OperaT High-Content Screening Platform
Alison Carter View Abstract View Poster
Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor 8 (mGluR8) using GIRK-mediated Thallium Flux Modulation in High-Throughput Screening
Emily Days View Abstract View Poster
Distribution of Cytochrome P450 Activity Across Known Drugs & Diverse Compound Collections
Henrike Veith View Abstract 
Division Arrested Cells Simplifying Assay Design & Increasing Flexibility
Steven Murphy View Abstract View Poster
Drug Discovery for Muscular Dystrophies
Xiaohua WU View Abstract View Poster
Drug Target Discovery In Huntington Disease  Cell Death Modifiers Identified With Adenoviral Shrna Technology
Richard Janssen View Abstract 
Drug-Drug Interactions of Human Cytochrome P450s by a New Electrochemical Array
Lok Hang Mak View Abstract 
Dual Purpose Cell Lines for Analysis of GPCR/Arrestin Interaction Using PathHunter & Natural Gq-coupling Using the Improved Calcium No-Wash PLUS Kit.
Tim Cloutier View Abstract 
Duplex HTS Assay Measured Simultaneously With Nano-TRF & fluorescence Lifetime Method
Lutz Pfeifer View Abstract View Poster
Dynamic Protein Affinity Chromatography SPE-LC-MS  Finding New Receptor Ligands in Complex Mixtures
Niels Jonker View Abstract 
Electroporation-based System for Genome Wide RNAi Screening
Johan Pihl View Abstract 
Endogenous Receptor Characterization in Normal Lung Cells by Cellular Dielectric Spectroscopy & RNA Interference
Sidney Bounds View Abstract 
Establishment of Functional Assays that Discriminate Between Neutral Antagonists & Inverse agonists
David Piwnica View Abstract 
Evaluation of AequoZenT Frozen Cells Starter Kit using the Aequorin Option for the FLIPR TETRA® System
Carole Crittenden View Abstract 
Evaluation of Nanoliter Transfer using Acoustic Droplet Ejection
Shekeba Ahmadyar View Abstract 
Evaluation of the New EnVision Monochromator Option
Miika Talvitie View Abstract View Poster
ExpressLC - A Platform For Fast, Reliable Separation-Based Assays Using Microflow LC Separations & Nanoliter Volume Detection
Hung-Yuan Cheng View Abstract 
Facing the Challenges of Supplying Assay Ready Plates Utilizing Special Library Sets to Obtain Novel Leads for the Hit to Lead Phase of Drug Discovery
Scott Mosser View Abstract 
FMAT Based Assay to Detect Antibodies Against Cell Surface Receptors
Hans-Willi Krell View Abstract 
From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction through the HIV-1 Integrase / human LEDGF-Case Study.
Philippe Guedat View Abstract 
From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction Through the HIV-1 Integrase / LEDGF-Case Study
Petra Tafelmeyer View Abstract 
Frozen Cells in Assay Plates for Instant Use in Cell-Based Screening
Oliver Klotzsche View Abstract View Poster
Frozen Human Primary Cells for High-Throughput Screening
Presenter Damon View Abstract View Poster
Full Automation of Magnetic Bead-Based  Luminex xMAP Cytokine Assays on the PerkinElmer JANUS® Automated Liquid Handling Platform
Gary Reznik View Abstract View Poster
Functional Characterization of Positive Allosteric Modulators of a7 Nicotinic Acetylcholine Receptors in IMR-32 Neuroblastoma Cells
Sujatha Gopalakrishnan View Abstract View Poster
Further Characterization of BIRB0796 using Multiple Target Class Profiling
Jonathan Clark View Abstract 
GDP Detection Using the Transcreener Technology
Karen Kleman-Leyer View Abstract 
GPCR Screening and Profiling Using Arrestin Reveals Unique Pharmacology for Compounds on Known Receptors and Provides a Platform For Oprhan GPCRs in Discovery and Repositioning Applications
Keith Olson View Abstract 
Hamamatsu Photonic FDSS7000  The New uHTS System with Multi-Dispense & Multi-Detection mode.
Sunao Hisada View Abstract 
Hepatocyte Culture Performance is Improved Over Current Methods When Cells are Grown On A Synthetic ECM-Mimetic Surface Topography
Michael Briggs View Abstract 
HIF-Prolyl Hydroxylase; Preparation of Multiple Reagents to Develop TR-FRET Assay for HTS
John Martin View Abstract 
High-content Image Analysis Using a Laser Scanning Microplate Cytometer
Sarah Payne View Abstract 
High-content Screening Assays for Neurotoxicity Profiling
Timothy Wheeler View Abstract 
High-content Screening Enables High-Throughput Screening
Presenter James View Abstract 
High-Density STEP Array Plates  A Novel Platform for Multiplexed GPCR Screening
Maria Ines Morano View Abstract 
High-Throughput Assays for de novo DNA Synthesis using Click Chemistry Detection Technology
Scott Clarke View Abstract 
High-Throughput Automation of Cisbio's IP-One HTRF® Assay using the BioRAPTR FRD Microfluidic Workstation & PARADIGMT Detection Platform
Amy Yoder View Abstract 
High-Throughput Cell Migration Assay with the IsoCyteT Laser Scanning Platform
Jayne Hesley View Abstract View Poster
High-throughput DNA Damage Assay for Breast Cancer Related Protein Markers using the IsoCyteT Platform
Evan Cromwell View Abstract 
High-Throughput Fluorescence Lifetime Based Assays for Protein Kinases
Robbie Thomas View Abstract 
High-Throughput Kinase Selectivity Profiling for Drug Discovery Applications
Aoife Gallagher View Abstract 
High-Throughput Screening for c-Jun N-terminal Kinase Inhibitors Using AlphaScreen in a 1536-well Format
Ping Zhu View Abstract 
High-throughput Screening Identifies Novel Inhibitors for Bacillus Anthracis O-succinylbenzoyl-CoA Synthetase
Yang Tian View Abstract 
High-Throughput Screening of HAUSP Inhibitors Using the TR-FRET Based DUB Substrate
Sunghou Lee View Abstract 
High-Throughput Secondary Screening-1400 Dose-Response Curves per Hour
Joe Olechno View Abstract 
HistopatholgicalSpectrum of Thymic Neoplasms  Nine-years Research Survey at a SAL Hospital, Ahmedabad, India
Sejal Goti View Abstract 
HitHunterT cAMP Assays  Versatile Assays Validated for Multiple Applications
Birgit Beyermann-Lopata View Abstract 
Homogeneous Time-Resolved Fluorescence-Based Assay for Phosphorylated Peptides Using a Generic Binder
Ulla Karhunen View Abstract 
HTRF as a Reliable Platform for Large Scale Kinase Profiling
Andrew Plater View Abstract 
HTRF® Deacetylation Assay  A new solution for HDAC/SIRT Screening
Francoise Degorce View Abstract 
HTRF® TranscreenerT ADP Assay  The New Solution for ADP Detection
Francoise Degorce View Abstract 
HTS Flow Cytometry of Multiplexed Targets HTS Flow Cytometry
Larry Sklar View Abstract 
Human Anti-Angiogenesis High-Throughput Screening Assay in 384-Well Format
Lakshmi Reddy View Abstract View Poster
Identification of Cytochrome P450 Mechanism-Based Inhibitors Using In vitro High-Throughput Assay
Weimin Tang View Abstract 
Identification of GPR23 Agonists, Antagonists & Inverse Agonists by High-throughput Screening
Paul Lee View Abstract 
Identification of MMP-12 Inhibitors by a Biosensor-Based Screening of a Fragment Library
Hans Muller-Kahle View Abstract View Poster
Identification of Novel Therapeutics for Treatment of Huntington's Disease - a Phenotypic Screening Cascade
Wolfgang Fecke View Abstract View Poster
Imaging PML Nuclear Bodies Using a High-content Imaging Platform
June Davies View Abstract View Poster
Immobilized Bead Assay System For Multiple Analyte Detection
Werner Lehmann View Abstract 
Improvements in Data Quality & Assay Performance Using Aequorin for Calcium Based Screening.
Jane Miller View Abstract 
Improvements in GPCR & calcium channel screening using Second Generation BD Calcium Assay Kits
Xiao Li View Abstract 
Improving the efficiency of 384 "mini-tube" Technology Using Mosquito® nanolitre pipetting
Florence Mazzarese View Abstract 
Improving the Efficiency Of 384 "mini-tube" Technology Using Mosquito® Nanolitre Pipetting
Russell Wheatcroft View Abstract 
In vitroToxicity Screening by Transcription Factor Activity Profiling
Keith Houck View Abstract 
Increasing Efficiency & Maintaining Quality  Running HTS on a 24/7 Schedule.
Lynda Cook View Abstract 
Integration of a Labcyte Echo 550 Liquid Handler® with a Velocity 11 Element SystemT
Jonathan Swaffield View Abstract 
Interrogation of the National Institutes of Health Small Molecule Repository for Protein Kinase D Inhibitors
Elizabeth Sharlow View Abstract 
Intracellular Nitric Oxide (NO) Generation Rates Correlate With Different No Synthases' Expression Levels, At The Resolution of Individual Living Cells
Vered Levy View Abstract 
Introducing the CellKeyT384 System, A Label-Free High-Throughput Cell-Based Assay for Functional Screening of Cellular Receptors
John Proctor View Abstract 
Introduction of a new TR-FRET Terbium Cryptate IP-One Tb, a new generation HTRF®  kit applied to GPCR Screening & Investigation
Eric Trinquet View Abstract 
Kinase Assay Development Using Acoustic Droplet Ejection Technology
Jean Shieh View Abstract 
Kinase Inhibitor Profiling & Compound Characterization on a Microfluidic Mobility-Shift Platform
Abbie Esterman View Abstract 
Kinase Selectivity Profiling on EZ ReaderT - 144 Kinases Against 12 Compounds in a Day.
Rajendra Singh View Abstract 
KingFisher® Flex - Flexible Automated Nucleic Acid, Protein & Cell Purification
Brenda Tierney View Abstract 
Label Free Holographic Biosensors for Drug Discovery
Eu Vian Tan View Abstract 
Label-free Analysis of Tissue Sections & Cells Using Laser Scanning Reflectance Imaging
Wayne Bowen View Abstract 
Label-Free Antibody Screening Sandwich Assay Using the Corning Epic® System
Jeffery Scibek View Abstract 
Label-Free Cell-Based Screening for GPCR Agonists & Antagonists using the Corning® Epic® System
David Randle View Abstract 
Label-Free Characterization of Proteins Using Acoustic Droplet Ejection Deposition & Advanced X-Ray Technology Measurement
Eva Birnbaum View Abstract View Poster
Label-Free Determination of Kinetic Constants for Small Molecule Binding to Proteins Using FortéBio's Octet RED Multi-Channel System
Charles Wartchow View Abstract 
Label-Free Optical Biosensor for Probing GPCR Ligand-Directed Functional Selectivity
Ann Ferrie View Abstract 
Label-Free Optical Biosensor for Probing Receptor Biology  Theory, Modeling & Applications
Ye Fang View Abstract 
Label-Free Optical Biosensor for Probing the Roles of Adenylate Cyclases in Signaling Integration of G Protein-Coupled Receptors
Elizabeth Tran View Abstract 
Leveraging Early Liability & Drug Safety Assessment by Integration of Innovative Screening Automation, High-Throughput Reagent Generation & Novel Bioassay Technology
Mary Ellen View Abstract 
LipoSignal  A Homogeneous, Cell-Free Assay for Screening for Modulators of GPCR Activation
David Sieg View Abstract 
Liquid Delivery Errors - The Impact of Laboratory Conditions on Pipetting Performance
Keith Albert View Abstract 
Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution using mosquito ®
Joby Jenkins View Abstract 
Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution Using mosquito ®
Florence Mazzarese View Abstract 
Luminescent Assay Optimization, Kinase Profiling, & uHTS Application
Sarah Shultz View Abstract View Poster
M-Screen  An Open-Source, Web-Based Application Package that Integrates Compound Management & High-Throughput Screening (HTS) Data Analysis
Renju Jacob View Abstract 
Maintaining 1536 Well Assay-Ready Microplate Reagent Integrity Using An Automatable Microplate Lid That Provides An Environmental Barrier Seal
Mark Rothenberg View Abstract 
Maintaining the Integrity of the Wyeth Liquid Samples
Husam Fayez View Abstract 
Mechanistic evaluation of natural product inhibitors of HIV-1 RNase
Alun Bermingham View Abstract 
Microchannel Assays Using Primary Tumor Cells, Co-culture & 3-dimensional Extracellular Matrices
Steve Hayes View Abstract 
Miniaturization of the HitHunterT cAMP XS+ Assay for Gs/Gi Screening in 1536 Well Plate Format.
Tom Wehrman View Abstract 
Mining Biological Screening Data in PubChem
Yanli Wang View Abstract 
MRC Technology's Drug Discovery Group; a Mechanism for De-risking Novel Targets Emerging from Academia.
Catherine Kettleborough View Abstract 
Multiplexed High-content Screening Assays for Cell Cycle Analysis & Cytotoxicity Profiling
Andrew Ball View Abstract 
Multiplexing Fluorescent & Chemiluminescent Live Cell Reporters to Dissect NFkB Signal Transduction Requirements
Cathy Olsen View Abstract 
Multiplexing HCV Replicon Luciferase Assay With Cell-Titer Blue Toxicity Assay In HTS Format
Sony Agrawal View Abstract 
nanoCFT Assay System  A Novel Tool for Mechanistic Studies
David Wyrick View Abstract 
nanoCFT Assay system  A Novel Tool for Mechanistic Studies
Part Two  Compound Profiling & Mechanism of Action
Christopher Hoyle View Abstract 
Navigating the High-content Imaging Process
David Cheo View Abstract 
New Aequorin Parental Cell Lines for Screening of GPCRs
Kenda Evans View Abstract View Poster
New SA-PE Conjugates Improve Critical Assay Parameters in Sandwich Immunoassays Performed Using Luminex® xMAP® Technology
Jo Wegstein View Abstract View Poster
New SA-PE Conjugates Reduce Capture-Antibody-Specific Background in Sandwich Immunoassays Performed Using Luminex® xMAP® Technology
Bruce Amsden View Abstract View Poster
Novel Ratiometric Phospholipase A2 Specific Enzyme Substrate with a Fluorescence Donor & Acceptor Pair
Hee Chol Kang View Abstract 
Old Assays, New Instrument  The Omega - High Speed, UV/Vis Spectrometer in a Microplate Reader
EJ Dell View Abstract 
One Stop Total Cell-Based Assay Solution with Invitrogen  From Assay Validation to High-Throughput Screening in Few Weeks
Mei Cong View Abstract 
Optimization of High-Throughput Ion Channel Screens Using Single Cell & Population Analyses
Meng Wu View Abstract 
Optimizing Nucleic Acid Detection by Altering Detection Chemistry
Heather Harding View Abstract View Poster
Optimizing Performance of the TranscreenerT ADP Assay for Commonly Used Multiwell Readers
Brad Larson View Abstract 
Overt Toxicity Screening Assay Using Live Z-TagSM Zebrafish
Timothy Baranowski View Abstract View Poster
PamChip Peptide Micro Array Technology  Applications in Kinase & Nuclear Receptor Research
Rene Houtman View Abstract 
PathHunterT NHR Protein Interaction Cell Lines  Study Nuclear Hormone Receptors Without Using Reporter Gene Assays
Theresa Schaub View Abstract 
PathHunterT Protein Interaction Assays for Analysis of Receptor Kinase Dimerization in Whole Cells.
Pyare Khanna View Abstract 
PCR Set Up in LightCycler® Carousels Using VERSA Workstations
Sikander Gill View Abstract View Poster
Performing Cytotoxicity Assays with Sleeping Cells & Thermo Scientific Microplate Readers
Marika Raitio View Abstract 
Permeability Studies Of Coumarins With New Modified Caco-2 Cell Model
Anna Galkin View Abstract 
Phosphodiesterases  A Novel Microfluidic Mobility-Shift Assay for Inhibitor Screening & Profiling
Seth Cohen View Abstract 
PhotoScreenT luminescent Calcium Assays  Applications on LumiLux® & FLIPRTETRA®
Giovanna Gualtieri View Abstract 
Predictive Cytotoxicity Measurements by Monitoring Heat Shock Proteins & the Cell Cycle in High-content Screening Cell-Based Assays
Suk Hong View Abstract View Poster
Primary Human Cells & BacMam Target Delivery in a Novel, High-Throughput Assay of hERG Function
Daniel Beacham View Abstract View Poster
Processware - An Order of Magnitude Improvement in LIMS Technology
Carl Hull View Abstract View Poster
Production of Biologically Active Chemokines In E. Coli
Quinn Lu View Abstract View Poster
Profiling for GPCR activation using DiscoveRx PathHunter B-Arrestin Technology
Justin Mika View Abstract 
Profiling the Activity of Proteasome Inhibitors Using Promega's Proteasome-GloT Cell-Based Assay
Khristofer Garcia View Abstract 
Purification & Enzymatic Characterization of Recombinant ADAMTS-5 in Aggrecan based MSD Assay
Rosalie Matico View Abstract 
QT Prolongation Assay Using Beating Cardiomyocyte Derived From Monkey ES Cell
Yasuyuki Asai View Abstract 
Quantitative Analysis of Angiogenesis & Cytoskeletal Formation with IN Cell Investigator
Ian Davies View Abstract View Poster
Quantitative High-Content Analysis of Intracellular Oxidative Stress & DNA Damage
Kay Opperman View Abstract View Poster
Quest Rhod-4T Calcium Indicator, a New Red Fluorescent for Screening GPCR & Calcium Channel Targets
Jinfang Liao View Abstract 
Rapid Generation of Epitope-Specific Recombinant Antibodies Using in vitro Selection Technology
Andreas Boll View Abstract View Poster
Rapid Improvement of Protein Stability by Thermal Profiling
William Chiou View Abstract 
Rapid Screening of 250 Supernatants Using Multiplexed SPR Technology & Real-Time Double Referencing
Mingde Zhu View Abstract 
Rapid Selective In Situ Screening Of Hybridomas in Semisolid Medium
Christopher Mann View Abstract View Poster
Real-time Reaction Monitoring & Enzyme Kinetics Measurements on the ExpressLC platform
Don Arnold View Abstract 
Receptor Selection & Amplification Technology  A Unique, Powerful Screening Platform for Drug Discovery
Fabrice Piu View Abstract 
Robust Kinetic Characterization of Moving Objects for Subcellular Time-lapse Assays
Seho Oh View Abstract 
Ru TR-FRET Assays  Evaluation of Two Acceptor Dyes & Comparison with Eu TR-FRET Assays
Lin Gao View Abstract 
Screening & Development of Antibodies For Use in High-content Immunofluorescent Microscopy.
Ting Qian View Abstract 
Screening against Proteases Comparison of QFRET Substrates & Miniaturization of a Plasma Protein Shift Assay
Frederic Masse View Abstract View Poster
Screening for Estrogen Receptor á (ERá) Ligands Using Nuclear Translocation Analysis
Angie Dull View Abstract 
Screening for Modulators of Notch Signaling using a Luciferase Complementation-Based Reporter
Ma Xenia Ilagan View Abstract 
Screening of a Kinase Enzyme Utilizing IMAP Assay & EnVision Multi-format Plate Reader Technologies.
Andrew Green View Abstract View Poster
Screening of Antimicrobial Compounds in Fungal Extracts against Gram-positive & Gram-negative Bacteria
Päivi Oinonen View Abstract 
Screening the NIH's Compound Library to Identify Inhibitor Probes of Human Immunodeficiency Virus Reverse Transcriptase-associated Ribonuclease H Activity.
Paul Johnston View Abstract 
Selective Detection of Pyrophosphate Using a Fluorogenic Pyrophosphate Sensor
Jianjun He View Abstract 
Serine/Threonine Kinase Profiling using the LANCE® Ultra KinaSelectT Ser/Thr Kit
Martina Bielefeld View Abstract View Poster
Simultaneous on-line bioaffinity screening and identity characterization of metabolic mixtures for fast and comprehensive metabolic profiling
Jeroen Kool View Poster
Slide-based Miniaturized Microtiter Plate for ELISA & Cell-based Assays
Namyong Kim View Abstract View Poster
Spatio-Temporal Cell Segmentation & Tracking for Automated Screening
Dirk Padfield View Abstract View Poster
Speeding the Compound Processing along the Research Super Highway
Timothy Zuzel View Abstract 
SPR Imaging, a Label-Free Method for the Analysis of Microarrays
Voula Kodoyianni View Abstract View Poster
Steady State Characterization of Death Associated Protein Kinase 1 Using Microfluidic Technology
Heidi Morgan View Abstract View Poster
Stem Cell-Derived Neurons In CNS Drug Discovery
Laura Jackson View Abstract 
Storage Solutions  New Technologies, New Applications
Simon Sheard View Abstract 
Strategies for Improving the Impact of High-Throughput Screening Campaigns
Lisa Elkin View Abstract View Poster
Stratgies to Reduce the Number of True Genotoxins Proceeding to Animal Testing
Richard Walmsley View Abstract 
Structural Mapping Of Gpcr Interactions With Ligands, Drugs, & Antibodies
Cheryl Paes View Abstract 
Sub-Cellular Resolution Genome Wide RNA Interference Analysis Within A Day
Neil Emans View Abstract View Poster
Successful Implementation of a Bio-Sample Store
Michele Gasser View Abstract View Poster
Taming the EDG Receptor Family with the TangoT Technology
Bonnie Hanson View Abstract 
Targeting & manipulating the STAT, M1-NFAT, & NFêB signaling pathways in  quantitative high-throughput screening (qHTS) using a laser-scanning fluorescence microplate cytometer
Natasha Thorne View Abstract 
Template-Directed Self-Assembly Imparts Biological Relevance to Standard In vitro Assays
Anthony Shrout View Abstract 
The Application of Microcarrier Technology to The Provision of Receptor Membranes For High-Throughput Screening
Rahman Ismail View Abstract 
The CellKeyT384 System Enables High-Throughput Screening with a Label-free Cell-Based Assay Platform.
Debra Gallant View Abstract 
The Effects of Pipette Tip Material & Sterilization on the Retention of Aqueous Liquids
John Bradshaw View Abstract 
The Great Transfer
Collette DeChard View Abstract 
The Impact of Automated Clone Selection on the Cell Line Generation Process
Alexandra Alderton View Abstract 
The Southern Research Molecular Libraries Screening Center
Gary Piazza View Abstract 
The Synergy Family of Readers, A Lower Cost High Performance Alternative for Running AlphaScreen Assays
Paul Held View Abstract View Poster
The use of Isothrmal Titration Calorimetry to Determine Enzyme Kinetic Constants for PP1-gamma Phosphatase
Brian Lightbody View Abstract 
The Use of Multi-Parametric High-Content Screening Assays to Monitor Cytotoxicity & Different Programmed Cell Death Pathways.
Krishna Vattem View Abstract View Poster
The Use of Quantitative, Cell-based, High-Content Screening Assays to Detect In vitro Genotoxicity & the Effect on Cell Cycle Checkpoints
Bhaskar Mandavilli View Abstract View Poster
The Use of QuickZymeT for the Identification of Novel Inhibitors of Anthrax Lethal Factor
We Report On Our Efforts Using the QuickZymeT Technology Platform for the Identification of Novel Inhibitors of Anthrax Lethal Factor (ALF)
Jan Schultz View Abstract View Poster
Three Kinase Screening Assays Using a Generic ADP Detection Method
Sandra Nelson View Abstract View Poster
Tools & Processes to Drive Data Quality & Throughput for Biochemical & Cellular Compound Profiling
Melissa Suzuki View Abstract View Poster
Toward Routine Assays in 200 nL Volumes
Michael Biros View Abstract 
Unveiling Drug Selectivity Via Functional Profiling & Multi-Prong Approach To Hit Validation Using ChemiScreenT GPCR Cell Lines
Mark Santos View Abstract View Poster
Use of a High-Throughput Phosphodiesterase Profiling Platform to Study Inhibitors Selectivity
Noushin Mirjalili View Abstract 
Use of IMAP TR-FRET Detection Mode for the IMAP AGC & CAMK Group Substrate Finder
Athena Panagiotakakos View Abstract 
Use of IMAP TR-FRET Detection Mode for the IMAP Tyrosine Kinase Group Substrate Finder
Parsa Safa View Abstract 
Use of PocketTip for Both Compound Storage & Screening
Manisha Jahla View Abstract 
Using Optical Sectioning to Improve the Performance of Cell Based Assays
HaiGuang Zhang View Poster
Using Surface Plasmon Resonance & the Acetylcholine Binding Protein to Screen for Ligands for the Nicotinic Acetylcholine Receptor
Kim Retra View Abstract 
Utilization of PathHunter Arrestin Cell Lines for Detection of Arrestin Biased Ligands & Compound Pharmacology Distinct from Second Messengers.
Vashti Lacaille View Abstract 
Utilizing Nano25 Low Volume Dispenser for Hit Optimization
Qinghua Xia View Abstract 
Utilizing Techniques in Developing & Optimizing Assay Paradigms to Increase Throughput in Screening Small Libraries & Special Compound Collections
Amanda Kemmerer View Abstract 
Validation of a Functional Screening Assay for Glycine Transporter 1 Inhibitors Using Cryopreserved Cells
Beth Ann McKenna View Abstract 
Validation of Automated High-Throughput Plasma Protein Binding Assays
Michael Shanler View Abstract 
Validation of Different Aequorin Mutants for GPCR Screening Using the FLIPRTETRA®  System with Aequorin Option
Matthew Hsu View Abstract 
Validation of Low Volume 1536 "Assay Ready" Compound Plates for a Nuclear Hormone Receptor Screen.
Bruno Becker View Abstract View Poster
Watchmaker® - Compound Generation by Combinatorial Genetics & Screening in Yeast
Markus Schwab View Abstract View Poster
What Structural Features Explain why Some Fragments of the Molecule are Important While Others are not?
Bogdan Kurchii View Abstract